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Tale of the Tape, Predictions: Louisville vs. Pitt
Louisville Cardinals linebacker Antonio Watts (9) celebrates his interception as Louisville Cardinals defensive lineman Denzel Lowry (45) cheers in the first half against Bowling Green at L&N Federal Credit Union Stadium in Louisville, Kentucky Sept. 20, 2025. Matt Stone/Courier Journal / USA TODAY NETWORK via Imagn Images

Louisville (3-0, 0-0 ACC) is set to face Panthers (2-1, 0-0 ACC) on Saturday, Sept. 27 at 12:00 p.m. EST at Acrisure Stadium in Pittsburgh, Pa. Here's how the Cardinals stack up against the Panthers:

*Mobile users can scroll left and right on the tables below*

Rankings

Offensive Statistics

Key: National Rank out of 136 FBS Teams (Value)

Defensive Statistics

Key: National Rank out of 136 FBS Teams (Value)

Special Teams Statistics

Key: National Rank out of 136 FBS Teams (Value)

Predictions:

- FPI Prediction: Per ESPN's Football Power Index, the Cardinals have an 57.0 percent chance to win against the Panthers. Louisville has an FPI rating of 7.8 (38th overall), whereas Pitt has an FPI rating of 2.2 (60th overall)

- SP+ Prediction: Per Bill Connelly's SP+ model, the Cardinals have a 58.39 percent chance to take down the Panthers. Louisville has an SP+ rating of 14.3 (26th overall), whereas Pitt has an SP+ rating of 8.2 (38th overall).

- Kelley Ford Prediction: Per the Kelley Ford ratings, the Cardinals have a 55 percent chance to defeat the Panthers. Louisville has a KFord rating of 10.1 (32nd overall), whereas Pitt has a KFord rating of 4.7 (53rd overall)

- College Football Insiders Prediction: Per College Football Insiders' IPR metric, the Cardinals have a 47.5 percent chance to take down the Panthers. Louisville has an EPA Margin of 0.007 (49th overall), whereas Pitt has an EPA Margin rating of 0.002 (63rd overall).

- Personal Prediction: Louisville 24, Pitt 21.

This article first appeared on Louisville Cardinals on SI and was syndicated with permission.

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