Watch: Louisville RB Isaac Brown Breaks 100 Yards On 6 Carries

Louisville running back Isaac Brown rushed for 126 yards and 2 touchdowns on just 6 carries during the Cardinals' 51-17 win over Eastern Kentucky in their 2025 season opener. Brown scored his first touchdown on a 31-yard burst through the hole early in the first quarter and then took a 68-yard run to the house in the 2nd quarter. Enjoy highlights from an impressive start to the season by Isaac Brown right here.