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Top MLB DFS Start‘em/Sit‘em For September 26th
- Aug 1, 2025; Miami, Florida, USA; Miami Marlins second baseman Xavier Edwards (9) reacts after scoring the winning run against the New York Yankees during the ninth inning at loanDepot Park. Mandatory Credit: Sam Navarro-Imagn Images

The MLB season is ending this weekend with a strong slate of games that could determine the postseason playing field and could help players win cash prizes in tonight’s top MLB DFS lineups and stacks. Friday’s 15-game slate will kick-start the weekend in style to end the season for fantasy players. With the last weekend here, fantasy players could win cash prizes in tonight’s top MLB DFS lineups and fantasy stacks.

Friday’s games will start the weekend with a bang, with the New York Mets going to Miami to take on the Marlins to fight for their postseason lives. Another game that could help fantasy players win cash prizes in tonight’s top MLB DFS lineups and stacks is the Milwaukee Brewers hosting the Cincinnati Reds, with the latter fighting for their postseason lives this weekend. 

With the MLB season ending in four days, fantasy players could win cash prizes in tonight’s top MLB DFS lineups and fantasy stacks. 

September 26th Top MLB DFS Lineup Starters 

1B Eric Wagaman, New York Mets at Miami Marlins ($3,000 – DraftKings/2,500-Fanduel)

To start Friday night’s top MLB DFS lineups, Eric Wagaman of the Miami Marlins should be in your lineups. During the losing effort against the Phillies, Wagaman had a day during the shutout loss. 

Wagaman has been playing well for the Marlins this season and could have another good game against the Mets. Fantasy players could see a multi-RBI game from the Marlins’ emerging first baseman tonight for fantasy lineups. 

2B Matt McLain, Cincinnati Reds at Milwaukee Brewers ($3,700 – DraftKings/2,700-Fanduel)

Matt McLain of the Cincinnati Reds should be in Friday night’s top MLB DFS lineups for fantasy players. In the close win against the Pirates, McLain had no plate appearances due to being there for a defensive spot. 

McLain has been struggling this season, but could break out against the Brewers tonight to keep their postseason dreams alive. Fantasy players could see a multi-hit game from the Reds veteran infielder against the Brewers tonight. 

OF Jarren Duran, Detroit Tigers at Boston Red Sox ($4,900 – DraftKings/3,500-Fanduel)

The last player to have for your fantasy lineups is Jarren Duran, of the Boston Red Sox, in tonight’s top MLB DFS lineups. In the losing effort against the Blue Jays, Duran went 1-3 with a double and a run. 

Duran has been having a strong season and could start the weekend off with a bang for fantasy players tonight. DFS players could see a multi-RBI game from the Red Sox’s veteran star. 

September 26th Top MLB DFS Benchwarmers 

OF Randy Arozarena, Los Angeles Dodgers at Seattle Mariners ($4,800 – DraftKings/3,300-Fanduel)

Randy Arozarena is the first player who should be on your top MLB DFS fantasy benches for Friday night’s games. In a win against the Rockies on Wednesday, Arozarena went 1-4 with three strikeouts, an RBI, and a double. 

Arozarena has been playing well, but could have a rough performance against the Dodgers tonight. Fantasy players could see a multi-strikeout game from the Mariners veteran slugger against the Dodgers’ pitching staff. 

SS Gunnar Henderson, Baltimore Orioles at New York Yankees ($4,700 – DraftKings/3,400-Fanduel)

Gunnar Henderson of the Detroit Tigers is another player who should be on your fantasy bench in tonight’s Top MLB DFS lineups. In a win against the Rays, Henderson went 2-4 with a strikeout. 

Henderson has been struggling this season and could have another poor performance against the Yankees tonight. Fantasy players could see a multi-strikeout game from the Orioles superstar against the Yankees at The Bronx tonight.

3B Mark Vientos, New York Mets at Miami Marlins ($3,400 – DraftKings/2,900-Fanduel) 

Mark Vientos of the New York Mets should be the last player on your top MLB DFS bench for Friday night’s games. During the Mets’ important win against the Cubs, Vientos went 0-4 with an RBI and a strikeout. 

Vientos has been struggling in the last week of September and could have another poor game against the Marlins tonight. Fantasy players could see a multi-strikeout game from the Mets’ star third baseman against their rivals.

Total Apex Media Stack Of The Day

Aug 3, 2025; Miami, Florida, USA; Miami Marlins shortstop Otto Lopez (6) and Miami Marlins left fielder Kyle Stowers (28) celebrate after winning the game against the New York Yankees at loanDepot Park. Mandatory Credit: Sam Navarro-Imagn Images

Friday’s top MLB DFS stack should be the Miami Marlins, Xavier Edwards, Jacob Marsee, and Heriberto Hernandez. The Marlins, even if they are eliminated from playoff contention, could have a great game to start the weekend for fantasy players. Fantasy players could see a great game from the Marlins lineup against the Mets tonight to end their postseason dreams. 

The first player for tonight’s top MLB DFS stack should be Edwards, who is having a breakout season for the Marlins. In a loss to the Phillies, Edwards went 0-1 with three walks and a strikeout. Edwards has been having a breakout season for the Marlins, and could have a great game against the Mets tonight. Fantasy players could see a multi-hit game from the Marlins’ emerging star infielder tonight. 

Another player, who could have a great game for fantasy players tonight, is Marsee, who is breaking out this September. During the losing effort against the Phillies, Marsee went 0-3 with a walk and was caught stealing. Marsee has been having a good season for the Marlins and could have a great game against the Mets tonight. DFS players for tonight’s game could see a multi-RBI game from the Marlins’ rookie against a sluggish Mets team tonight.

The last player for tonight’s top MLB DFS stack should be Hernandez, who is coming out of nowhere for fantasy players. In the shutout loss to the Phillies, Hernandez went 0-1 in a pinch-hitting appearance. Hernandez has been playing well for the Marlins, and could start the last weekend of the season strong against the Mets. Fantasy players could see a home run from the Marlins’ young outfielder against their division rivals to start the weekend for fantasy lineups. With the MLB season ending in three days, fantasy players could start the weekend strong with tonight’s top MLB DFS lineups and win cash prizes.

This article first appeared on Total Apex Fantasy Sports and was syndicated with permission.

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