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Top MLB DFS Start‘em/Sit‘em For September 27th
- Sep 29, 2024; Chicago, Illinois, USA; Cincinnati Reds shortstop Elly De La Cruz (44) hits a two-run triple during the tenth inning against the Chicago Cubs at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

With the MLB season ending tomorrow, fantasy players could keep the weekend going and have fantasy players win cash prizes in today’s top MLB DFS lineups and fantasy stacks. Saturday’s 15-game slate will keep the weekend games going with this afternoon’s slate of games. The MLB season is ending tomorrow, and fantasy players could win cash prizes this Saturday as the weekend heats up. 

Saturday’s games will start the weekend with a bang, with the Arizona Diamondbacks taking on the San Diego Padres, with the Diamondbacks’ postseason lives hanging in the balance for the weekend. Another game that could help fantasy players win cash prizes in tonight’s top MLB DFS lineups and stacks is the Toronto Blue Jays hosting the Tampa Bay Rays to end their homestand this season. 

The MLB season is ending tomorrow, and fantasy players could win cash prizes today to celebrate the second-to-last day of the season. 

September 27th Top MLB DFS Lineup Starters 

SS Anthony Volpe, Baltimore Orioles at New York Yankees ($3,600 – DraftKings/2,700-Fanduel)

To start Saturday afternoon’s top MLB DFS lineups, Anthony Volpe of the New York Yankees should be in your lineups. In the win against the Orioles, Volpe went 1-4 in a crushing win against the Orioles. 

Volpe has been having a strong September and could have a good game today for fantasy lineups. Fantasy players could see a multi-hit game from the Yankees’ young star shortstop for today’s top MLB DFS lineups. 

OF Daulton Varsho, Tampa Bay Rays at Toronto Blue Jays ($4,600 – DraftKings/3,600-Fanduel)

Daulton Varsho of the Toronto Blue Jays should be in Saturday afternoon’s top MLB DFS lineups for fantasy players. In a win against the Rays, Varsho went 1-4 with a double, a run, and a strikeout. 

Varsho has been having a solid season with 20 home runs, and could have another one before a potential division title win. Fantasy players could see a multi-RBI game from the Blue Jays outfielder today. 

1B/3B Miguel Vargas, Chicago White Sox at Washington Nationals ($3,600 – DraftKings/2,800-Fanduel)

The last player to have for your fantasy lineups is Miguel Vargas, of the Chicago White Sox, in this afternoon’s top MLB DFS lineups. During a win against the Nationals, Vargas went 2-5 with an RBI and a strikeout. 

Vargas has been having a solid weekend for the White Sox and could have another great game against the Nationals. DFS players could see a multi-RBI game, which could help fantasy players win cash prizes.

September 27th Top MLB DFS Benchwarmers 

2B Brandon Lowe, Tampa Bay Rays at Toronto Blue Jays ($5,300 – DraftKings/3,100-Fanduel)

Brandon Lowe is the first player who should be on your top MLB DFS fantasy benches for Saturday afternoon’s games. In the loss to the Blue Jays, Lowe went 1-4 with a strikeout in the close defeat. 

Lowe has been sluggish this September and could have a weak game against the Blue Jays again. Fantasy players could expect a multi-strikeout game from the Rays veteran infielder for today’s slate of games. 

OF Tyler O’Neill, Baltimore Orioles at New York Yankees ($3,600 – DraftKings/2,900-Fanduel)

Tyler O’Neill of the Baltimore Orioles is another player who should be on your fantasy bench in this afternoon’s Top MLB DFS lineups. In a brutal loss to the Yankees, O’Neill went 1-4 with a home run, a walk, and a strikeout. 

O’Neill has been having a nightmare season, and could have another weak performance today for fantasy lineups. DFS players could see a hitless game from the Orioles veteran for fantasy lineups.

1B Pete Alonso, New York Mets at Miami Marlins ($5,100 – DraftKings/3,500-Fanduel) 

Pete Alonso of the New York Mets should be the last player on your top MLB DFS bench for Saturday afternoon’s games. In a crushing loss against the Marlins, Alonso went 1-4 with an RBI double and two strikeouts. 

Alonso has been struggling in September, and could have another poor game against the Marlins. Fantasy players could see another multi-strikeout game from the Mets slugger that could end their nightmare season. 

Total Apex Media Stack Of The Day

Cincinnati Reds right fielder Jake Fraley (27) crosses the plate on a two-run home run in the fourth inning of the MLB National League game between the Cincinnati Reds and the Los Angeles Dodgers at Great American Ball Park in downtown Cincinnati on Tuesday, July 29, 2025. The Reds led 3-2 after four innings.

Saturday’s top MLB DFS stack should be the Cincinnati Reds, Elly De La Cruz, TJ Friedl, and Gavin Lux. The Reds are getting ready for a postseason run and could have a great game against the Brewers, potentially clinching a playoff spot. Fantasy players could win cash prizes with the Reds in today’s top MLB DFS lineups and fantasy stacks. 

The first player to have for today’s top MLB DFS stack is Cruz, who could have a great game against the Brewers. In the close win against the Brewers, Cruz went 1-4 during an important win against their rivals. De La Cruz has been improving for the Reds, and could keep the weekend going with a strong game against the Brewers. Fantasy players could see a multi-RBI game from the Reds’ young emerging star against the Brewers tonight.

Another player who could have a great game is Friedl, who is emerging as a star for the Reds this September. In the win against the Brewers, Friedl went 2-3 with a walk during the win at Milwaukee. Friedl has been having a solid season for the Reds and could have a strong game against the Brewers tonight. DFS players could see a home run from the Reds veteran outfielder against the Brewers to potentially clinch a playoff spot today. 

The last player to have for today’s top MLB DFS stack is Lux, after a strong game against the Brewers. In an important win against the Brewers, Lux went 2-4 with two runs and a strikeout. Lux has been having a solid season and could keep his hot weekend going with a strong game for fantasy lineups. DFS players could see a multi-hit game from the Reds veteran infielder against the Brewers to help solidify their postseason spot to end the season. With the MLB season having only two games left, fantasy players could win cash prizes to keep the weekend going for today’s top MLB DFS lineups.

This article first appeared on Total Apex Fantasy Sports and was syndicated with permission.

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