Fantasy football owners frequently ask themselves, "Who do I start?" Trust our decades of expertise for precise matchup evaluations and adept player insights to give you the winning edge! Each week, we'll highlight some of the less obvious starters and contrast those bright spots with fantasy anchors who can sink your chances of coming away with a win.
Also See: Running Backs | Wide Receivers | Tight Ends | Defense/Special Teams
Caleb Williams, Chicago Bears vs. Dallas Cowboys
After a strong first half of Week 1, Williams has played six quarters of sketchy football. Nevertheless, the fantasy results were not dreadful (23.7-point average). In Week 3, he heads on the road in front of a raucous crowd. Given the rash of quarterback injuries, you'd be hard-pressed to find a better gamble than Williams against a Dallas unit that surrendered the most fantasy points to QBs in 2024 and second through the first two weeks of this campaign. Russell Wilson torched them for 36.8 points in Week 2 with CB DaRon Bland (foot) absent, a game after Jalen Hurts racked up 25.8, albeit mostly on the ground. The alarming part is Dallas has generated the fourth-most pressure on QBs thus far. Bland has a chance to play, but this defense will struggle to keep up with a deep receiving corps. Williams also has ground skills to add bonus points, and he'll have to throw if the Bears cannot stop Dallas' offense.
C.J. Stroud, Houston Texans at Jacksonville Jaguars
The Jags allowed 235.5 and two scores per game to open the year, creating the seventh-best matchup to date. One more TD was added via the ground. Although rushing is not Stroud's forte, we see this defense only fall a lone spot. Now, one concern here is Jacksonville has tallied five interceptions to lead the NFL, and that is with a modest pass rush (4 sacks, 20.5% pressure rate). Facing Bryce Young and Jake Browning didn't hurt, but Stroud hasn't been sharp in 2025, either. He has thrown a single TD and one pick in two games, averaging 197.5 yards. Stroud has positive history vs. the Jaguars, going for at least 280 yards and two scores in three of the four battles. The worst outing was 242 yards and a TD.
Russell Wilson, New York Giants vs. Kansas City Chiefs
Fresh off a monster stat line of 450 yards and three scores, it's no surprise gamers desperate for a QB play would be interested in rolling with Wilson. It's not all bad vs. the Chiefs as this group hasn't forced a takeaway yet, ranks midrange with five sacks, and was embarrassed in the opener Justin Herbert. Jalen Hurts threw for only 101 yards and needed a rushing TD to even get into double-digit fantasy points. How comfortable are you with an erratic quarterback behind a suspect line going up against a KC team desperate to avoid an 0-3 start? Stranger things have happened, but Wilson's ceiling is low and the risk is high. Play him only if you must.
Michael Penix Jr., Atlanta Falcons at Carolina Panthers
This one isn't necessarily a knock against Penix himself. He certain could play well against the Panthers, but his inclusion is primarily based on how the offense will attack. Carolina is remarkably awful at stopping running backs, and Bijan Robinson is as lethal as any back in the game right now. Plus, Tyler Allgeier reminded everyone last week that he's still a high-caliber rusher. Penix may not throw more than 25 times. Carolina has allowed only two total passing TDs this season and 199 yards per game. Is that a blip? Probably, but the unlikely trend should continue one more week. Penix dropped over 30 points in last year's finale on this team when Drake London went bonkers, so it's a somewhat risky sit, but he's not entirely avoidable by any means.
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