Steven Bisig-Imagn Images

49ers' Kyle Juszczyk reportedly set to clear concussion protocol

Originally posted on 49ers Webzone | By David Bonilla | Last updated Sep 19, 2025 4:22 PM ET

The San Francisco 49ers are expected to have fullback Kyle Juszczyk available for Sunday's NFC West showdown against the Arizona Cardinals. Juszczyk suffered a concussion early in Week 2 against the New Orleans Saints and did not return. He and defensive back Siran Neal have been navigating the league's concussion protocol this week.

NBC Sports Bay Area's Matt Maiocco reports that neither player wore the no-contact jerseys on Friday, which they wore during the Wednesday and Thursday practices. That signals that they have reached the final stage of the NFL's return-to-play process.

"It looks as if FB Kyle Juszczyk and DB Siran Neal have received full clearance out of the concussion protocol," Maiocco shared.

It looks as if FB Kyle Juszczyk and DB Siran Neal have received full clearance out of the concussion protocol.
Neither was wearing the blue no-contact jersey, which signifies they have reached the fifth and final stage of the NFL's return-to-play process.
— Matt Maiocco (@MaioccoNBCS) September 19, 2025

Head coach Kyle Shanahan will provide injury updates after practice, including the official game statuses of key players like Juszczyk, quarterback Brock Purdy (toe), and wide receiver Jauan Jennings (ankle, shoulder).

Both the 49ers and Cardinals enter Sunday's pivotal matchup at Levi's Stadium undefeated, with records of 2-0. San Francisco aims to extend its winning streak while dealing a significant blow to a divisional rival.

This article first appeared on 49ers Webzone and was syndicated with permission.

More must-reads: