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49ers vs. Broncos in Week 4: Preview, odds
Cary Edmondson-Imagn Images

The San Francisco 49ers will face the Denver Broncos in the final of three straight games at Levi's Stadium. This matchup marks the 17th meeting all-time between the two teams and the first time the Broncos have traveled to Levi's Stadium since the 2018 season. The 49ers look to improve to 6-3 at home against Denver and start the season 4-0 for the second time in four seasons.

Previous game

The 49ers are coming off a 36-30 victory over the Arizona Cardinals. On offense, QB Brock Purdy completed 15 of 27 pass attempts for 297 yards and four touchdowns, finishing with a 133.8 passer rating. TE George Kittle caught six passes for a team-high 82 yards and two touchdowns, while WR Mike Evans caught three for 34 yards and a touchdown. WR Deebo Samuel added a career-long 80-yard touchdown.

RB Christian McCaffrey tallied 15 carries for 75 yards and one touchdown on the ground, along with four receptions for 41 yards through the air.

Defensively, San Francisco held the Cardinals to 93 rushing yards and recorded 2.0 sacks of Cardinals QB Jacoby Brissett. LB Fred Warner led the unit with a team- and career-high 17 tackles. CB Renardo Green added a career-high 13 tackles and one pass defensed, while DL Ogbo Okoronkwo and DL Keion White each recorded a sack.

The 49ers Communications staff provided the above breakdown.

Below is everything you need to know to follow the upcoming game.

When does the game start?

Sunday, October 4 at 1:25 p.m. PT

Where is the game being played?

Levi's Stadium in Santa Clara, California

Who are the head coaches?

49ers: Kyle Shanahan
Broncos: Sean Payton

Betting Odds

As of September 30, the 49ers are favored by 2.5 points in this game, with an over/under set at 48 points, per BetMGM.

What channel is the game on?

Network: CBS
Play-By-Play: Kevin Harlan
Color Analyst: Trent Green
Sideline Reporter: Melanie Collins

Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.

What areas will receive the broadcast?

The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.

Where can I stream the game?

NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the full game once the matchup is complete.

Bay Area fans can stream the game through the official 49ers app or at 49ers.com.

Where can I listen to the radio broadcast?

49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.

Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.

Broncos Radio
Denver area fans can listen on KOA 850 AM and 94.1 FM, where Dave Logan and Rick Lewis will call the game.

National Radio
Fans can listen to the game on Sports USA Radio, where Larry Kahn and Ron Rivera will call the game.

Streaming
NFL+ subscribers can listen to the game through that service.

Game discussion

Fans can discuss the game within our Niner Talk forum.

How has this series played out historically?

Matchups: 16
Series Record: Series is tied, 8-8
49ers Home Record vs. Broncos: 49ers lead series 5-3
49ers Away Record vs. Broncos: Broncos lead series 5-2
First Meeting: 10/25/70, 49ers win 19-14, at SF
Last Meeting: 9/25/22, Broncos win 11-10, at Den.
Current Streak: Lost 1
Longest 49ers Win Streak: 3 (1/28/90 – 12/15/97)
Longest Broncos Win Streak: 4 (11/18/79 – 10/9/88)
Most 49ers Points: 55 (1/28/90): 49ers win 55-10, at NO (s)
Most Broncos Points: 42 (10/19/14): Broncos win 42-17, at Den.
49ers Shutouts: None
Broncos Shutouts: None
(s) – Super Bowl XXIV (Superdome – New Orleans, LA)

49ers Notes

  • 49ers can begin 4-0 for the 4th time since 1990 (1990, 2019 & 2023).
  • QB Brock Purdy passed for 297 yards & 4 TDs vs. 0 INTs for a 133.8 rating in Week 3, his 5th-career game with 4+ TD passes. Is the only QB with 2+ TD passes & a 100+ rating in each of the 1st 3 weeks. Has 285+ pass yards, 2+ TD passes & a 115+ rating in 4 of his past 5 home starts.
  • RB Christian McCaffrey had 116 scrimmage yards (75 rush, 41 rec.) & his 65th-career rush TD last week. Has 2,836 scrimmage yards (113.4 per game) & 25 TDs (18 rush, 7 rec.) in 25 home games with SF since 2022. Can become the 4th player ever (Warrick Dunn & HOFers Eric Dickerson & Marshall Faulk) with 6,000+ scrimmage yards with 2 teams.
  • TE George Kittle led the team with 6 catches for 82 yards & 2 TDs in Week 3, his 9th-career game with 2+ TD catches. Aims for his 3rd in a row with 80+ rec. yards & a TD catch. Since 2017, ranks 2nd among TEs in receptions (607) & rec. yards (8,182) & 3rd in rec. TDs (55). Had 7 catches for a career-high 210 yards & a TD in his last home meeting (12/9/18), the 2nd-most rec. yards in a single game by a TE all-time.
  • WR Mike Evans had his 110th-career rec. TD last week, 10th-most in NFL history.
  • WR Deebo Samuel had 94 scrimmage yards (80 rec., 14 rush) & his 29th-career rec. TD in Week 3. Aims for his 3rd in a row vs. Den. with 60+ scrimmage yards.
  • LB Fred Warner had a career-high 17 tackles & a TFL last week. Ranks tied for 2nd with 33 tackles in 2026. Can appear in his 125th career game in Week 4.
  • LB Dre Greenlaw aims for his 3rd in a row with 8+ tackles.
  • DL Keion White aims for his 3rd in a row with a sack.
  • DL Ogbo Okoronkwo had his 18th-career sack in Week 3.
  • CB Renardo Green had a career-high 13 tackles last week. Has a PD in 2 of 3 games this season.
  • CB Deommodore Lenoir had his 1st PD of the season in Week 3.

Broncos Notes

  • QB Bo Nix totaled 3 TDs (2 pass, 1 rush) in Week 3, his 5th-career game with 2+ TD passes & a rush TD. Has a TD pass in 12 of his past 13 on the road. Since 2024, is 1 of 2 QBs (Josh Allen) with 50+ TD passes (58) & 10+ rush TDs (10). Is 10-1 as a starting QB vs. NFC.
  • RB J.K. Dobbins had a season-high 53 scrimmage yards (49 rush, 4 rec.) last week.
  • RB RJ Harvey led the team & tied his career high with 6 catches last week. Has 4+ catches in 5 of his past 6 on the road.
  • WR Courtland Sutton had 8 catches for 97 yards in the last meeting.
  • WR Jaylen Waddle ranks 4th among players drafted in 2021 in receptions (384), rec. yards (5,189) & rec. TDs (26).
  • WR Pat Bryant had his 2nd-career TD catch last week.
  • DL Zach Allen had his 35th-career sack last week.
  • DT Malcolm Roach aims for his 3rd in a row with a TFL.
  • LB Nik Bonitto had his 1st sack of the season in Week 3.
  • LB Alex Singleton aims for his 4th in a row with 8+ tackles. Ranks tied for 2nd with 33 tackles in 2026. Had an INT-TD in his only career game at SF (10/4/20 with Phi.).
  • LB Justin Strnad had a TFL & PD last week & aims for his 3rd in a row with a TFL.
  • CB Pat Surtain II aims for his 3rd in a row with 6+ tackles. Had 2 PDs in the last meeting.
  • CB Riley Moss aims for his 5th in a row with a PD.
  • S Brandon Jones led the team with 12 tackles & had his 15th-career TFL last week. Aims for his 4th in a row with 5+ tackles.
  • S Talanoa Hufanga had 5 tackles, a sack, 3 PDs & 2 INTs, including a 66-yard INT-TD, in Week 3, becoming the 1st player since 1982 with a sack, 2 INTs & a 50+-yard INT-TD in a single quarter of a single game. Had 214 tackles, 14 PDs & 7 INTs in 49 games (2021-24) with SF. Aims for his 3rd in a row with a TFL & 4th in a row with 5+ tackles.

This article first appeared on 49ers Webzone and was syndicated with permission.

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