49ers vs. Seahawks odds, spread, total: NFL 'Thursday Night Football'

The 49ers (2-3) face the Seahawks (3-2) in Week 6 of the NFL season, with kickoff set for 8:15 p.m. ET at Lumen Field in Seattle. Here’s an early look at the 49ers vs. Seahawks odds, spread and total for this Sunday afternoon matchup.

The 49ers are three-point favorites over the Seahawks in the latest NFL odds for Week 6, with the over/under set at 46.5.

49ers

The 49ers were blanked in the second half of their Week 5 loss, blowing a 23-10 lead as they fell 24-23.

Their four drives in the half ended in an interception, downs, fumble and another interception. San Francisco is 2-3, both SU and ATS.

Seahawks

Seattle fell 29-20 to a shorthanded Giants team that flew across the country. The offensive line failed them, as Geno Smith was sacked seven times.

Meanwhile, they couldn’t get the ground game going as Kenneth Walker had five carries for 19 yards and Zach Charbonnet two carries for 11. Seattle’s dropped two in a row to move to 3-2 SU but are just 1-3-1 ATS.