Cardinals vs. Bills prediction: Odds, lines, best bets, Expert Picks for NFL Week 1

Cardinals vs. Bills Picks

SPREAD

We have no pick on the Cardinals-Bills spread. Arizona is a popular NFL pick, though.

MONEYLINE

We have no bet on the moneyline.

TOTAL

With high winds in Orchard Park on Sunday, our betting pick is on the under.

Cardinals vs. Bills Pick: Under 47.5

Cardinals vs. Bills Odds

Sunday, Sept. 8

1 p.m. ET

CBS

Odds via FanDuel. Get up-to-the-minute NFL odds here.

• Cardinals vs. Bills Point Spread: Cardinals +6.5 | Bills -6.5
• Cardinals vs. Bills Total: Over/Under 47.5
• Cardinals vs. Bills Moneyline: Cardinals +240 | Bills -300

How to Watch Cardinals vs. Bills

Cardinals vs. Bills is scheduled for 1 p.m. ET live from Highmark Stadium on Sunday. The game is live on CBS and other streaming platforms, such as YouTube TV.

Cardinals-Bills Betting Trends

• 59% of bets and 65% of the money are on Arizona to cover the spread.
• 71% of bets and 33% of the money are on the under.
• 88% of bets and 81% of the money on the moneyline are on Buffalo.

Cardinals vs. Bills: NFL Week 1 Picks

By Simon Hunter

If you're a fan of "The Favorites," then you'll know this was a line I liked right when lines came out after the schedule was released in May. I thought we were getting a good number on the Bills, but I got a bunch of sharp calls that bullied me into getting off of my position.

I really like the Cardinals, but there are too many question marks here. Kyler Murray is back and Marvin Harrison Jr. is in, but I'm still not entirely sold. I want to see Murray's connection with Harrison before backing Arizona.

The line moving from 5.5 to 6.5 this week has made this pick complicated. The potential for a tease on the Bills is now very high. I initially liked the Bills, but I'm going to sit this one out and see how the matchup plays out.

Best Bet for Cardinals vs. Bills

By Kevin Roth

This likely ends up as the windiest game of Week 1.

In full transparency, I prefer hitting wind unders with sustained winds of 20 mph or greater, and this game likely falls just a hair short of that criteria. That being said, I still think we'll see it impacting one or two deeper throws or long field goals, and the difference between an over and an under can be one field goal or one would-be-touchdown ball that hangs up in the wind.

I expect winds in Orchard Park to be consistently 15-20 mph with wind gusts of 20-25 mph. It certainly won't impact every play, but it might just be enough to tilt the odds in our favor.

Pick: Under 47.5

About the Author

Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

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