Dec 8, 2024; Kansas City, Missouri, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) reacts after a first down during the second half against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images Jay Biggerstaff-Imagn Images

Chiefs vs. Chargers Contains Imperative Fantasy Storyline

Originally posted on Kansas City Chiefs on SI
By Andy Quach | Last updated Sep 4, 2025 12:00 PM ET

A narrative was spun over the offseason that the Kansas City Chiefs could have an offensive resurgence in 2025. Between their blowout loss in Super Bowl LIX to the Philadelphia Eagles, the weapons they have available to them, and the losses they suffered on the other side of the ball, it seems that Patrick Mahomes and the Chiefs' attack will have to return to its dominant ways for Kansas City to continue its dynastic run.

That perked the ears of fantasy football players across the country. If it's true that Head Coach Andy Reid and his team are putting a renewed focus on O, Mahomes, Travis Kelce, Rashee Rice, Xavier Worthy, Isiah Pacheco, and more could turn out to be high-level fantasy contributors.

That's all just speculation, though. The Chiefs haven't proven anything yet. Come Week 1 against the Los Angeles Chargers, the Chiefs could affirm all the optimism surrounding their offense, or they could fall flat in the season opener. Or worse yet, they could go out and win yet again behind the strength of their defense and with a measured, low-volume offensive game plan.

Week 1 will be revelatory for the Chiefs

The 2025 NFL season opener will be a good litmus test for the Kansas City Chiefs. The Los Angeles Chargers have a stout defense and have built their team under Head Coach Jim Harbaugh similarly to how KC has operated in the past two seasons, relying on their D, running game, and clutch quarterback play from Justin Herbert to win games.

If Patrick Mahomes and the Chiefs' offense can have an explosive performance against the Chargers, it'll bode well for their fantasy prospects for the entire 2025 season. FantasyPros' Josh Shepardson will be watching closely to see how Kansas City approaches the matchup:

"The Chiefs spent their first-round pick on Josh Simmons to shore up Mahomes’ blindside. Simmons fell because his final collegiate season was cut short by a torn patellar tendon. Yet, Simmons was healthy in training camp and played in all three preseason games. Could he help unlock the deep passing attack if he hits the ground running by awarding Mahomes more time to unleash deep balls? Maybe. The Chiefs start their regular season against the Chargers in Brazil on Friday, and it will be the first opportunity for Kansas City to turn the clock back to a more exciting, fantasy-friendly offense."

.@Chiefs QB Patrick Mahomes is ranked No. 5 on the NFL Top 100 Players of 2025!@NFLFilms @PatrickMahomes pic.twitter.com/c2a4MoxMuQ
— NFL (@NFL) September 2, 2025

If Head Coach Andy Reid and the Chiefs' offense come into their matchup against Los Angeles' defense with guns blazing, it'll be an extremely encouraging sign for their fantasy owners for the rest of the season.

Find us on X (Twitter) @KCChiefsOnSI and @Domminchella to follow along with our Chiefs' Week 1 updates.

This article first appeared on Kansas City Chiefs on SI and was syndicated with permission.

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