The 25-year-old left guard was injured during practice on Monday and scheduled to have surgery Tuesday, per the report.
Nelson's injury comes just days after new starting quarterback Carson Wentz sustained the same injury.
BREAKING: Quenton Nelson has the same foot injury as Carson Wentz. He’s scheduled to have surgery in Indy later today with the same doctor as Wentz. Similar 5-12 week timeline for Nelson— Mike Wells (@MikeWellsNFL) August 3, 2021
Wentz, who was acquired by Indianapolis from Philadelphia in March, reportedly wanted to avoid surgery ahead of his first campaign with the Colts.
All options are on the table, including a minor surgical procedure. The hope is to avoid it, but it’s possible. Either way, if Carson Wentz misses games it’s not likely to be many. https://t.co/Td3c1unuAd— Ian Rapoport (@RapSheet) July 30, 2021
There is no definite timeline for when either Wentz or Nelson will return.
Nelson was drafted by Indianapolis with the sixth overall pick in the 2018 NFL Draft. He has been voted First-Team All-Pro in all three seasons so far.
The Colts kick off their preseason on Aug. 15 hosting the Carolina Panthers.