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It's more than clear that the 2025 Bills are expected to be a very different version of their past selves
Mark Konezny-Imagn Images

Could it finally be the Buffalo Bills' year?

They are certainly set up for success based on all the external factors heading into the 2025 season, so it's now up to them. 

According to ESPN's David Purdum, the Bills have opened as favorites in all 17 of their regular-season games this season. They are the only NFL team to get that honor. 

And that includes tough matchups against the Baltimore Ravens, Kansas City Chiefs, and Cincinnati Bengals. But, what makes it better is that those three teams will have to travel to Buffalo and play in front of Bills Mafia at Highmark Stadium. 

Based on Sharp Football Analysis' Strength of Schedule Chart, the Bills have the fifth easiest, with only the San Francisco 49ers, New England Patriots, New Orleans Saints, and Atlanta Falcons in front of them. 

2025 NFL Strength of ScheduleSharp Football Analysis

The Bills were also given a Week 7 bye, which is considered to be one of the more coveted spots. A team can be assigned a bye week as early as Week 5, while the latest is Week 14. For Week 7, it is somewhat in the middle, with the team set to play six games before and 11 after. 

Buffalo has the reigning NFL MVP and now with this schedule, they have all they need to get over that final hump and get a Super Bowl championship.

Here is the Buffalo Bills' 2025 schedule

  • Week 1: vs Baltimore Ravens (SNF, Sunday, Sept. 7, 8:20 p.m. ET)
  • Week 2: at New York Jets (Sunday, Sept. 14, 1:00 p.m. ET)
  • Week 3: vs Miami Dolphins (TNF, Thursday, Sept. 18, 8:15 p.m. ET)
  • Week 4: vs New Orleans Saints (Sunday, Sept. 28, 1:00 p.m. ET)
  • Week 5: vs New England Patriots (Sunday, Oct. 5, 8:20 p.m. ET)
  • Week 6: at Atlanta Falcons (MNF, Monday, Oct. 13, 7:15 p.m. ET)
  • Week 7: BYE
  • Week 8: at Carolina Panthers (Sunday, Oct. 26, 1:00 p.m. ET)
  • Week 9: vs Kansas City Chiefs (Sunday, Nov. 2, 4:25 p.m. ET)
  • Week 10: at Miami Dolphins (Sunday, Nov. 9, 1:00 p.m. ET)
  • Week 11: vs Tampa Bay Buccaneers (Sunday, Nov. 16, 1:00 p.m. ET)
  • Week 12: at Houston Texans (TNF, Thursday, Nov. 20, 8:15 p.m. ET)
  • Week 13: at Pittsburgh Steelers (Sunday, Nov. 30, 4:25 p.m. ET)
  • Week 14: vs Cincinnati Bengals (Sunday, Dec. 7, 4:25 p.m. ET)
  • Week 15: at New England Patriots (Sunday, Dec. 14, 1:00 p.m. ET)
  • Week 16: at Cleveland Browns (Sunday, Dec. 21, 1:00 p.m. ET)
  • Week 17: vs Philadelphia Eagles (Sunday, Dec. 28, 4:25 p.m. ET)
  • Week 18: vs New York Jets (TBD)

This article first appeared on A to Z Sports and was syndicated with permission.

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