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Latest Cardinals and 49ers injury report ahead of Week 3 matchup

Originally posted on Burn City Sports
By Tanner Tortorella | Last updated Sep 19, 2025 1:06 PM ET

GLENDALE – After Thursday’s practice, the Arizona Cardinals and San Francisco 49ers released players’ participation on their latest injury report. Notably names for Arizona was rookie CB Will Johnson remaining out of practice due to a groin injury, with his status for Sunday unknown. For San Francisco much of their key players, like Christian McCaffrey and Nick Bosa, missed Wednesday practice but just because of rest.

However, starting 49ers QB Brock Purdy remains limited in practice, with doubt surrounding him playing in Week 3.

Cardinals-49ers injury report:

Cardinals:
- CB Will Johnson (Groin) – Didn’t Practice
- OL Kelvin Beachum (Rest) – Full
- OL Will Hernandez (Knee) – Limited
- OL Paris Johnson Jr. (Knee) – Limited
- CB Max Melton (Knee) – Limited
- TE Tip Reiman (Foot) – Limited
- LB Cody Simon (Concussion) – Full
- DL Dante Stills (Elbow) – Full
49ers:
- DE Nick Bosa (Rest) – Full
- G Spencer Burford (Knee) – Didn’t Practice
- DE Tetur Gross-Matos (Knee) – Limited
- WR Jauan Jennings (Ankle/Shoulder) – Didn’t practice
- FB Kyle Juszcyzk (Concussion) – Limited
- RB Christian McCaffrey (Calf) Full
- S Siran Neal (Concussion) – Limited
- T Trent Williams (Knee) – Limited
- QB Brock Purdy (Toe/Left Shoulder) – Limited
- WR Jordan Watkins (Calf) – Limited

San Francisco battled injuries all last year and still have struggled to keep healthy with key players in and out of the lineup. Arizona has had the same problem during training camp, losing two starting cornerbacks, and then last week with two players, Garrett Williams and L.J. Collier, were added to injury reserve.

This article first appeared on Burn City Sports and was syndicated with permission.

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