Los Angeles Rams vs. Buffalo Bills odds, predictions, picks and best bets

The 10-2 Buffalo Bills travel to Los Angeles to take on the 6-6 Rams in an important interconference showdown.

It's been a season of ups and downs for the Rams, who are in a tight battle for the NFC West lead. They're coming off a road win over the New Orleans Saints, where running back Kyren Williams led the way with 104 rushing yards. 

Williams is the heart of Los Angeles' offense, racking up 1,071 total scrimmage yards and 12 touchdowns so far this year. The Rams' defense has been solid against the pass, but has struggled against the run.

The Bills are one of the hottest teams in the NFL right now, winner of their last seven games. Quarterback Josh Allen is a leading MVP candidate, throwing for 2,691 yards, rushing for 334 yards, and racking up 26 total touchdowns.

Buffalo ranks in the top 10 in both offense and defense, and have already clinched the AFC East title. It needs keep winning to stay within striking distance of the Kansas City Chiefs for the No. 1 seed in the AFC, trailing them by one game. 

Here are the best odds, bets, and predictions for this matchup

*Odds from BetMGM and subject to change

Rams vs. Bills Moneyline

Rams: +185
Bills: -225

The Bills are a matchup nightmare for any team in the league. Their running game is physical, and Allen has pinpoint accuracy throwing the ball. It appears that rookie wide receiver Keon Coleman is set to return from injury for this game, making Buffalo's offense even more dangerous.

As for the Rams, you never really know what you're going to get from them. Some weeks they look like an NFC powerhouse, and others they seem completely overmatched. It's possible we see L.A.'s best in this game, but there's just no consistency to predict that. I'm taking the Bills and laying the points, therefore avoiding the moneyline.

Rams vs. Bills Spread

Rams: +4.5 (-110)
Bills: -4.5 (-110)

The Bills have been blowing people out left and right, and the Rams can't be trusted to put up a valiant fight. I like Buffalo to win pretty comfortably. 

Rams vs. Bills Over-Under 49 total points

Over: -110
Under: -110

This game has potential to be a shootout, but L.A.'s offense is the wildcard in that scenario. I'll play it safe and take the under.