Yardbarker
NFL predictions, odds for every game: Week 2 NFL schedule
Pictured: An NFL football during the 2024 season. Getty Images.

NFL predictions, odds for every game: Week 2 NFL schedule

Originally posted on Action Network  |  Last updated Sep 15, 2024 12:30 PM ET

Our experts have taken a look up and down the NFL Week 2 schedule, and they've come away with their best bets for every game.

The tightest spread at the moment is in Rams vs. Cardinals, where the Cardinals are currently just 1-point favorites (-1). The biggest spread is in Raiders vs. Ravens, as Baltimore is an 8.5-point favorite (-8.5) against Las Vegas. The highest over/under is in Bucs vs. Lions at 51.5 points, and the lowest total is the over/under 36.5 in Steelers vs. Broncos.

But those are just the superlatives. Let's get to the Week 2 NFL odds, our expert picks, and NFL predictions for every game.

Week 2 NFL Predictions

NFL Odds for Week 2

  • Chargers vs. Panthers Spread: Chargers -5
  • Saints vs. Cowboys Spread: Cowboys -6
  • Raiders vs. Ravens Spread: Ravens -8.5
  • Bucs vs. Lions Spread: Lions -7.5
  • Jets vs. Titans Spread: Jets -4
  • Seahawks vs. Patriots Spread: Seahawks -3
  • Browns vs. Jaguars Spread: Jaguars -3
  • 49ers vs. Vikings Spread: 49ers -4.5
  • Colts vs. Packers Spread: Colts -2.5
  • Giants vs. Commanders Spread: Commanders -1.5
  • Rams vs. Cardinals Spread: Cardinals -1
  • Bengals vs. Chiefs Spread: Chiefs -6.5
  • Steelers vs. Broncos Spread: Steelers -2.5
  • Sunday Night Football Bears vs. Texans Spread: Texans -6
  • Monday Night Football Falcons vs. Eagles Spread: Eagles -6

No matter what game you're looking for, Action Network goes deep on ALL the key NFL matchups at their NFL betting hub, where you'll find the odds, picks and predictions you need to win! 

Week 2 NFL Schedule

Los Angeles Chargers at Carolina Panthers

Sunday, Sept 15

1 p.m. ET

CBS

Chargers Odds
Spread Total Moneyline
-5
-110
 38.5
-110o / -110u
 -240
Panthers Odds
Spread Total Moneyline
+5
-110
 38.5
-110o / -110u
 +195

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Chargers vs. Panthers Spread: Chargers -5
  • Chargers vs. Panthers Over/Under: 38.5 points
  • Chargers vs. Panthers Moneyline: Chargers -240, Panthers +195
  • Chargers vs. Panthers Pick, Prediction: Panthers to cover the spread

New Orleans Saints at Dallas Cowboys

Sunday, Sept. 15

1 p.m. ET

FOX

Saints Odds
Spread Total Moneyline
+6
-105
 47
-110o / -110u
 +235
Cowboys Odds
Spread Total Moneyline
-6
-115
 47
-110o / -110u
 -290

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Saints vs. Cowboys Spread: Cowboys -6
  • Saints vs. Cowboys Over/Under: 47 points
  • Saints vs. Cowboys Moneyline: Cowboys -290, Saints +235
  • Saints vs. Cowboys Pick, Prediction: Cowboys -19.5 alt spread

Las Vegas Raiders at Baltimore Ravens

Sunday, Sept. 15

1 p.m. ET

CBS

Raiders Odds
Spread Total Moneyline
+8.5
-110
 41
-110o / -110u
 +325
Ravens Odds
Spread Total Moneyline
-8.5
-110
 41
-110o / -110u
 -425

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Raiders vs. Ravens Spread: Ravens -8.5
  • Raiders vs. Ravens Over/Under: 41 points
  • Raiders vs. Ravens Moneyline: Ravens -425, Raiders +325
  • Raiders vs. Ravens Pick, Prediction: Ravens to cover the spread

Tampa Bay Buccaneers at Detroit Lions

Sunday, Sept. 15

1 p.m. ET

FOX

Buccaneers Odds
Spread Total Moneyline
+7.5
-110
 51
-110o / -110u
 +300
Lions Odds
Spread Total Moneyline
-7.5
-110
 51
-110o / -110u
 -380

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Bucs vs. Lions Spread: Lions -7.5
  • Bucs vs. Lions Over/Under: 51 points
  • Bucs vs. Lions Moneyline: Lions -380, Bucs +300
  • Bucs vs. Lions Pick, Prediction: Under

New York Jets at Tennessee Titans

Sunday, Sept. 15

1 p.m. ET

CBS

Jets Odds
Spread Total Moneyline
-4
-110
 41
-110o / -110u
 -200
Titans Odds
Spread Total Moneyline
+4
-110
 41
-110o / -110u
 +165

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Jets vs. Titans Spread: Jets -4
  • Jets vs. Titans Over/Under: 41 points
  • Jets vs. Titans Moneyline: Jets -200, Titans +165
  • Jets vs. Titans Pick, Prediction: Titans to cover the spread

Seattle Seahawks at New England Patriots

Sunday, Sept. 15

1 p.m. ET

FOX

Seahawks Odds
Spread Total Moneyline
-3
-110
 38.5
-110o / -110u
 -165
Patriots Odds
Spread Total Moneyline
+3
-110
 38.5
-110o / -110u
 +140

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Seahawks vs. Patriots Spread: Seahawks -3
  • Seahawks vs. Patriots Over/Under: 38.5 points
  • Seahawks vs. Patriots Moneyline: Seahawks -165, Patriots +140
  • Seahawks vs. Patriots Pick, Prediction: Under

Cleveland Browns at Jacksonville Jaguars

Sunday, Sept. 15

1 p.m. ET

CBS

Browns Odds
Spread Total Moneyline
+3
-105
 41.5
-110o / -110u
 +140
Jaguars Odds
Spread Total Moneyline
-3
-115
 41.5
-110o / -110u
 -165

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Browns vs. Jaguars Spread: Jaguars -3
  • Browns vs. Jaguars Over/Under: 41.5 points
  • Browns vs. Jaguars Moneyline: Jaguars -165, Browns +140
  • Browns vs. Jaguars Pick, Prediction: Browns to cover the spread

San Francisco 49ers at Minnesota Vikings

Sunday, Sept. 15

1 p.m. ET

CBS

49ers Odds
Spread Total Moneyline
-4.5
-110
 46.5
-110o / -110u
 -240
Vikings Odds
Spread Total Moneyline
+4.5
-110
 46.5
-110o / -110u
 +195

Odds via bet365. Get up-to-the-minute NFL odds here.

  • 49ers vs. Vikings Spread: 49ers -4.5
  • 49ers vs. Vikings Over/Under: 46.5 points
  • 49ers vs. Vikings Moneyline: 49ers -240, Vikings +195
  • 49ers vs. Vikings Pick, Prediction: 49ers to cover the spread

Indianapolis Colts at Green Bay Packers

Sunday, Sept. 15

1 p.m. ET

FOX

Colts Odds
Spread Total Moneyline
-2.5
-105
 41
-110o / -110u
 -135
Packers Odds
Spread Total Moneyline
+2.5
-115
 41
-110o / -110u
 +115

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Colts vs. Packers Spread: Colts -2.5
  • Colts vs. Packers Over/Under: 41 points
  • Colts vs. Packers Moneyline: Colts -135, Packers +115
  • Colts vs. Packers Pick, Prediction: Packers to cover the spread

New York Giants at Washington Commanders

Sunday, Sept. 15

1 p.m. ET

FOX

Giants Odds
Spread Total Moneyline
+1.5
-110
 43.5
-110o / -110u
 +105
Commanders Odds
Spread Total Moneyline
-1.5
-110
 43.5
-110o / -110u
 -125

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Giants vs. Commanders Spread: Commanders -1.5
  • Giants vs. Commanders Over/Under: 43.5 points
  • Giants vs. Commanders Moneyline: Commanders -125, Giants +105
  • Giants vs. Commanders Pick, Prediction: Giants moneyline

Los Angeles Rams at Arizona Cardinals

Sunday, Sept. 15

4:05 p.m. ET

FOX

Rams Odds
Spread Total Moneyline
+1
-115
 48
-110o / -110u
 -110
Cardinals Odds
Spread Total Moneyline
-1
-105
 48
-110o / -110u
 -110

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Rams vs. Cardinals Spread: Cardinals -1
  • Rams vs. Cardinals Over/Under: Cardinals -110, Rams -110
  • Rams vs. Cardinals Moneyline: 48 points
  • Rams vs. Cardinals Pick, Prediction: Rams to cover the spread

Cincinnati Bengals at Kansas City Chiefs

Sunday, Sept. 15

4:25 p.m. ET

CBS

Bengals Odds
Spread Total Moneyline
+6.5
-110
 48
-110o / -110u
 +235
Chiefs Odds
Spread Total Moneyline
-6.5
-110
 48
-110o / -110u
 -290

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Bengals vs. Chiefs Spread: Chiefs -6.5
  • Bengals vs. Chiefs Over/Under: 48 points
  • Bengals vs. Chiefs Moneyline: Chiefs -290, Bengals +235
  • Bengals vs. Chiefs Pick, Prediction: Bengals to cover the spread

Pittsburgh Steelers at Denver Broncos

Sunday, Sept. 15

4:25 p.m. ET

CBS

Steelers Odds
Spread Total Moneyline
-2.5
-115
 36.5
-110o / -110u
 -150
Broncos Odds
Spread Total Moneyline
+2.5
-105
 36.5
-110o / -110u
 +125

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Steelers vs. Broncos Spread: Steelers -2.5
  • Steelers vs. Broncos Over/Under: 36.5 points
  • Steelers vs. Broncos Moneyline: STeelers -150, Broncos +125
  • Steelers vs. Broncos Pick, Prediction: Broncos to cover the spread

'Sunday Night Football:' Chicago Bears at Houston Texans

Sunday, Sept. 15

8:20 p.m. ET

NBC

Bears Odds
Spread Total Moneyline
+6
-110
 45.5
-110o / -110u
 +210
Texans Odds
Spread Total Moneyline
-6
-110
 45.5
-110o / -110u
 -260

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Bears vs. Texans Spread: Texans -6
  • Bears vs. Texans Over/Under: 45.5 points
  • Bears vs. Texans Moneyline: Texans -260, Bears +210
  • Bears vs. Texans Pick, Prediction: Under

'Monday Night Football:' Atlanta Falcons at Philadelphia Eagles

Monday, Sept. 16

8:15 p.m. ET

ESPN

Falcons Odds
Spread Total Moneyline
+6
-110
 46.5
-110o / -110u
 +210
Eagles Odds
Spread Total Moneyline
-6
-110
 46.5
-110o / -110u
 -260

Odds via bet365. Get up-to-the-minute NFL odds here.

  • Falcons vs. Eagles Spread: Eagles -6
  • Falcons vs. Eagles Over/Under: 46.5 points
  • Falcons vs. Eagles Moneyline: Eagles -260, Falcons +210
  • Falcons vs. Eagles Pick, Prediction: Under

Our Bark Bets sports betting newsletter has the news, picks and analysis smart bettors are using to win. Sign up today!

More must-reads:

Customize Your Newsletter

Yardbarker +

Get the latest news and rumors, customized to your favorite sports and teams. Emailed daily. Always free!

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.