San Francisco 49ers quarterback Brock Purdy (13) has had his share of troubles this season. Albert Cesare/The Enquier / USA TODAY NETWORK

NFL Week 10: San Francisco 49ers vs. Jacksonville Jaguars betting picks, preview

By Griffin Carroll | Last updated Nov 10, 2023 1:08 PM ET

The game of the weekend might very well be this inter-conference matchup between San Francisco and Jacksonville. Both teams are coming off their bye, and we're seeing value here.

San Francisco 49ers vs. Jacksonville Jaguars: Betting Odds

Spread: San Francisco -3, Over/under: 44.5 points, San Francisco -170 | Jacksonville +142

San Francisco slipped heading into their bye week, losers of three straight games. While the 49ers had some injuries, notably to LT Trent Williams and WR Deebo Samuel, it's still noteworthy how much Brock Purdy has struggled of late.

Purdy has thrown five interceptions to three touchdowns during this losing streak, mustering only 17 points in all three games. Samuel is expected back this weekend, but Williams may miss another week, which would be a blow here against a viable Jaguars pass rush.

Jacksonville sits at 6-2 atop the AFC South, winners of five straight games. The Jaguars have been getting some elite play out of their run game, but we're all still waiting for Trevor Lawrence to deliver the season we expected. Elite defensive play has been the name of the game for the Jags success, with DVOA ranking them as the third-best defensive team.

Jacksonville is tied for the NFL's best record ATS at 6-2, and they're an even 4-4 to the over. San Francisco is 4-4 ATS and 5-3 to the over.

Betting Picks for San Francisco vs. Jacksonville

Jaguars +3

Is it possible that the bye week halted Jacksonville's momentum and gave San Francisco a chance to catch their breath and get back on track? Perhaps. However, nothing we've seen suggests that this is what the spread should be.

Jacksonville deserves to be home favorites, and if their defense can make life difficult on Brock Purdy and continue to force him to turn the ball over, they're going to win this game.

San Francisco is 1-3 ATS on the road, and they've had some issues slowing down WRs, which would make this a good time for Calvin Ridley and Christian Kirk to notch some big games through the air.

Give us the home dogs to keep this one close against a 49ers team with some growing issues.

Check out Yardbarker's betting hub for odds, picks, predictions and analysis — and start winning TODAY!

Griffin Carroll

Griffin Carroll is focused on bringing you the betting numbers that matter. With a focus on the NFL, NHL and NBA, Griffin relies on a data-driven betting approach for prop bets, spread picks and over/unders.

More must-reads: