NFL Week 6 Betting Guide

Tampa Bay Buccaneers @ Pittsburgh Steelers

Spread: Tampa Bay -8.5
Total: 45.5 points

No defense has allowed more 20+ yard passes than Pittsburgh, and they're also allowing the sixth-most yards per pass attempt. Tom Brady and his finally healthy receivers should be able to pick apart the Steelers with ease through the air. Every quarterback has gone over their passing yards total against Pittsburgh this season, and Brady has thrown for 350+ yards in two straight.

Betting: Tom Brady over 277.5 passing yards (-115 DK)

New York Jets @ Green Bay Packers

Spread: Green Bay -7
Total: 45.5 points

The Jets' pass protection has been a problem, while the Packers know how to rush the passer. After a letdown game, expect Aaron Rodgers and this offense to take it to the Jets, who are riding high on a two-game winning streak.

Betting: Packers -7

Minnesota Vikings @ Miami Dolphins

Spread: Minnesota -3
Total: 45.5 points

It's Skylar Thompson under center for Miami, making his first career start. This matchup looks fruitful for Minnesota on both sides of the football. They should be able to pressure Thompson and frazzle the rookie, and their passing attack is in a good spot to pick apart a vulnerable secondary. We'll take the Vikings in an easy win.

Betting: Vikings -3

Baltimore Ravens @ New York Giants

Spread: Baltimore -5.5
Total: 45 points

It still shocks us that New York is 4-1, and at some point their success has to come crashing down, right? We're going to leave this game's spread alone and instead turn to Lamar Jackson. The Giants' defense has done a good job slowing down the passing game, but we're seeing a trend of quarterbacks breaking off rushing gains. Justin Fields went for 52 on the ground and Baker Mayfield racked up 35 yards rushing. Jackson is averaging 89.25 rushing yards per game over the past four. We'll gladly take his over.

Betting: Lamar Jackson over 57.5 rushing yards (-110 DK)

San Francisco 49ers @ Atlanta Falcons

Spread: San Francisco -5
Total: 44.5 points

All we know is Atlanta is 5-0 ATS. Can they cover the spread in every game? Probably not, but they continue to show an ability to keep games close, and back home and getting five points, we'll take them to cover here. San Francisco should be able to generate pressure on Marcus Mariota, but Mariota is a passer who can become a weapon should he be forced out of the pocket.

Betting: Falcons +5

Cincinnati Bengals @ New Orleans Saints

Spread: Cincinnati -2
Total: 43 points

This Bengals offense has been a severe disappointment, and that's started along the offensive line. This may be a nice opportunity for Cincinnati to get right. PFF has New Orleans' pass rush graded as 25th in the league and they are averaging only 2.0 sacks per game. It's time for the Burrow-Chase connection to have a big day.

Betting: Bengals -2

Jacksonville Jaguars @ Indianapolis Colts

Spread: Indianapolis -2
Total: 42 points

The Colts are 5-0 to the under this year, and Jacksonville have mustered only 20 points of offense the past two weeks. The Jaguars defense is a bit better than you might think, and Indianapolis' offense has looked anemic. We'll bet the under here.

Betting: Under 42 points

Carolina Panthers @ Los Angeles Rams

Spread: Los Angeles -10
Total: 41.5 points

We've got two teams here that are 1-4 ATS, both with glaring issues. For Los Angeles, their offensive line has been disastrous. Carolina's issues may or may not have been rooted in coaching, and the Panthers fired Matt Rhule this week. We're biting and taking the points as we look for some more inspired play from Carolina under interim coach Steve Wilks.

Betting: Panthers +10

Arizona Cardinals @ Seattle Seahawks

Spread: Arizona -2
Total: 50.5 points

Eno Benjamin will be the starting running back for Arizona this weekend, and Seattle has been gashed on the ground every single week. The Seahawks have allowed three straight 100-yard rushers, and with the volume coming Benjamin's way, we like a big game from the young back.

Betting: Eno Benjamin over 52.5 rushing yards (-115 FD)

Buffalo Bills @ Kansas City Chiefs

Spread: Buffalo -2.5
Total: 54 points

This is projected to be the highest scoring game of the weekend, and for good reason. We should have some fun with this one, it looks like the best game to load up a touchdown parlay with these two high-powered offenses. The Chiefs have allowed the third-most touchdowns to wide receivers this year and the Bills have allowed the seventh-most to running backs.

Betting: Gabriel Davis & Clyde Edwards-Helaire TD parlay (+417 FD)

Dallas Cowboys @ Philadelphia Eagles

Spread: Philadelphia -6.5
Total: 42 points

Sunday Night Football should be a treat in what is a massive NFC East game between the 4-1 Cowboys and 5-0 Eagles. 6.5-points is a lot, even for the undefeated Eagles at home. Cooper Rush is 5-0 ATS as a starter, and Dallas has had Philly's number the past few years.

Betting: Cowboys +6.5

Denver Broncos @ Los Angeles Chargers

Spread: Los Angeles -4.5
Total: 45.5 points

The Chargers are 4-1 ATS this season, while the Broncos are 1-4 ATS. We have yet to see a big game from Justin Herbert, but it looks like Keenan Allen may be returning to the field on Monday. Russell Wilson and the Broncos have looked horrible. We're betting on the home team here.

Betting: Chargers -4.5