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NFL Week 7: Chargers vs. Cardinals odds, spread, total for 'Monday Night Football'
Pictured: Kyler Murray of the Arizona Cardinals. Photo by Patrick McDermott/Getty Images

Chargers vs Cardinals Odds for NFL Week 7

Chargers
Monday, Oct 21
9:00 p.m. ET
ESPN+
Cardinals
Chargers Odds
Spread
Total
Moneyline
-2.5 -110
43.5 -110o / -110u
-140
Cardinals Odds
Spread
Total
Moneyline
+2.5 -110
43.5 -110o / -110u
+120

The Chargers (3-2) face the Cardinals (2-4) in Week 7 of the NFL season, with kickoff set for 9 p.m. ET at State Farm Stadium in Glendale. Here’s an early look at the Chargers vs. Cardinals odds, spread and total for this Monday night matchup.

The Chargers are 2.5-point favorites over the Cardinals in the latest NFL odds for Week 7, with the over/under set at 43.5.


Chargers

A Chargers team that relies heavily on the run let Justin Herbert air it out last week far more than he had all year. He had his most completions (21), yards (237), and attempts (34) as his injured ankle looked much improved.

The Bolts’ defense continues to be a force to be reckoned with as they lead the league in points against. Los Angeles is 3-2 SU and 3-1-1 ATS.


Cardinals

Arizona’s up-and-down season continued Sunday in a 34-13 loss to the Packers. The Cardinals’ offense has run hot and cold, and they might be without star wideout Marvin Harrison, as the rookie suffered a concussion early in Green Bay.

Arizona’s defense has struggled mightily, as they’re giving up the fifth-most points per game in the league (27.2). The Cardinals are 2-4 SU and 3-3 ATS.

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