Oct 27, 2024; Houston, Texas, USA; Houston Texans quarterback C.J. Stroud (7) at the line of scrimmage during the game against the Indianapolis Colts at NRG Stadium. Mandatory Credit: Troy Taormina-Imagn Images Troy Taormina-Imagn Images

Texans Open as Clear Road Underdogs vs. Colts

Originally posted on Houston Texans on SI | By Jared Koch | Last updated Nov 25, 2025 9:39 AM ET

The Houston Texans are heading into their Week 13 matchup against the Indianapolis Colts looking like the clear underdogs in the eyes of sportsbooks.

According to odds from FanDuel Sportsbook, the Texans are +4.5 (+180 ML) on the road against their division rival Colts, making for Houston's second straight week as betting underdogs.

Texans Open as +4.5 Underdogs vs. Colts

So far this season, Houston's 5-6 against the spread, but just 0-3 as underdogs on the road––those three losses coming against the LA Rams, Jacksonville Jaguars, and Seattle Seahawks.

Now in Week 13, the Texans will have another tall challenge against the Colts and their potent offensive unit, led by Daniel Jones and Jonathan Taylor, to take them atop the AFC South with an 8-3 record and as the number-one scoring unit through the first half of the season.

Jay Biggerstaff-Imagn Images

But Houston might be the best matchup on paper to take on that offensive prowess. The Texans are the number-one scoring defense through the first 12 weeks of the year, well-rounded in both the front seven and their secondary, and coming off a red-hot week of logging eight sacks on the reigning MVP Josh Allen and the Buffalo Bills on Thursday Night Football.

In Houston's last five games against the Colts, they've rattled off a record of 4-0-1, sweeping their latest season series in 2024. The last time the Texans lost in Indianapolis came back in 2021 when Carson Wentz was at the helm of their offense, throwing for two touchdowns in a duel against Davis Mills.

This time around, the stakes are look much higher, as Houston will be searching a fourth-straight win and their chance at a 7-5 record on the season, while for the Colts, they'll be trying to extend their lead of the AFC South they've commanded throughout the entire year thus far.

Kickoff between the Texans and Colts lands on Sunday, November 30th at 12 p.m. CT in Lucas Oil Stadium.

Odds refresh periodically and are subject to change.

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This article first appeared on Houston Texans on SI and was syndicated with permission.

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