The must-see game from each week of the 2025 NFL schedule

The Ravens and Bills are usually in the AFC conversation, but Baltimore has gotten the best of the series lately, winning three of the last four regular-season matchups dating back to 2018. Josh Allen is hoping to change Buffalo's fortunes in the first Sunday Night Football game of the year.

We don't have to wait long for a Super Bowl LIX rematch, as the Eagles visit the Chiefs in Week 2. Coming off a Week 1 game in Brazil, the Chiefs will be looking to get vengeance on the reigning Super Bowl champs.

The Lions pride themselves on toughness head coach Dan Campbell, while the Ravens have usually been the tougher team in matchups during John Harbaugh's tenure. The team squads will clash in Week 3 in a matchup that also features two of the premier running backs in the league with Jahmyr Gibbs and Derrick Henry.

Week 4 features two Monday Night Football games, headlined by Cincinnati at Denver. The Bengals are renowned for their offense with Joe Burrow and company, while the Broncos have built an elite defense.

Sean Payton and Bo Nix have the Broncos back on the map after last season, but they'll be tested in a Week 5 visit to Philly. Denver's strong offensive line will also have its hands full against the Eagles' front seven.

The Lions have had one of the most explosive offenses in football recently, and hope to keep that trend going despite the loss of coordinator Ben Johnson. The Chiefs are also mainstays among the league's top offenses, led by Patrick Mahomes and Andy Reid's play calling.

The late-night MNF doubleheader game features Houston in a visit to Seattle. Sam Darnold is out to prove his breakout season in Minnesota wasn't a fluke, while C.J. Stroud is hoping to rebound from a sophomore slump in 2024.

J.J. McCarthy takes over under center for the Vikings this season following the departure of Sam Darnold and will be tested by the Chargers defense in Week 8. The Michigan alum will also have the opportunity to face his college head coach, Jim Harbaugh.

Chiefs vs. Bills is always appointment television, and the Week 9 matchup doesn't look any different. While KC has owned Buffalo in the playoffs recently, Josh Allen's team has won the last four regular-season matchups.

Philadelphia handled Green Bay in Week 1 of the regular season and the playoffs last year, and the two teams look like formidable NFC favorites again this season. Jordan Love and the Packers will get the advantage of hosting the matchup for the first time since 2020.

We're set for some creative offense in Week 11 when Kliff Kingsbury's Commanders offense faces Mike McDaniel's Dolphins. The game is also significant for the NFL, as it takes place in Madrid, Spain, for the first time.

The Bucs made the playoffs last season on the strength of Baker Mayfield and a solid offense, but will be tested against the Rams in Week 12. LA is hoping for one last run with the addition of Davante Adams, helping Matthew Stafford.

Thanksgiving in Dallas is a given, but this year's matchup is fascinating. The Cowboys will host Patrick Mahomes and the Chiefs in the traditional affair.

Cincinnati is hoping to rebound after a disappointing 2024 season, as Joe Burrow visits Josh Allen's Bills in Buffalo. The Bengals won the last two matchups, including a playoff win following the 2022 regular season.

Lions vs. Rams matchups are often profiled due to the 2021 that swapped Jared Goff and Matthew Stafford. As Stafford approaches the end of his career, this could be the final matchup between the two quarterbacks and with potentially enormous NFC ramifications.

Seattle has high hopes after remaking their offense in the offseason, adding Sam Darnold and Cooper Kupp after losing DK Metcalf and Tyler Lockett. They host the Rams in the final stretch of the regular season in what could be a key NFC West matchup on Thursday Night Football.

Last year's Week 18 matchup between the Lions and Vikings was considered at the time to be one of the most consequential regular season games ever, deciding the NFC North and homefield advantage. The game ultimately didn't play a major role in the Super Bowl, but the team are hopeful it will have a similar impact this season on Christmas Day. Detroit has owned the series recently, winning the last five head-to-head matchups.

The rivalry between the Ravens and Steelers is always a classic, even as Pittsburgh's 2025 season looks murky without a clear starter at quarterback. Baltimore halted Pittsburgh's four-game winning streak in the series last December.