Week 10 Fantasy Football Sleepers to Help You Win

The running back position gets hit hard enough by injuries and byes this week, but it's nothing like what we'll have to fight through at wide receiver.

You'll need extra help at tight end, and quarterback is on the thin side, too, so expect a fairly low-scoring week in general.

Once the must-start players are locked in, fantasy football owners face challenging weekly lineup decisions for the remaining slots, and knowing the best sleeper picks gives you the winning edge. Join us each week of the NFL season as we uncover those hidden gems to help you hoist a fantasy championship trophy!

QB Marcus Mariota, Washington Commanders vs. Detroit Lions

Mariota is starting with Jayden Daniels (elbow) sidelined, and the veteran brings rushing skills to the field that could come in handy this week, especially for those in superflex formats. This game carries one of the week’s higher totals, and with Detroit favored by at least 8.5 points we should expect plenty of pass attempts from Mariota. Stream him if you need reasonably safe fill-in play.

RB Devin Singletary, New York Giants at Chicago Bears

Singletary is coming off a season-high 56% of the snaps and 48% of the touches while partnering with Tyrone Tracy Jr. in effort to replace the injured Cam Skattebo (ankle). His 10 utilizations produced 51 yards and 7.1 PPR returns. Given bye-week losses, injuries at the position, and facing a top-10 fantasy matchup, Singletary has a sniff of utility this week.

WR Alec Pierce, Indianapolis Colts vs. Atlanta Falcons (Berlin)

Pierce offers a vertical aspect not found in Michael Pittman Jr., and the Colts sent a message about their confidence in the deep threat after trading away Adonai Mitchell in the Sauce Gardner deal. An overseas game always injects a hint of uncertainty, and Pierce isn't a lock against an Atlanta D that has been among the top-10 toughest opponents for opposing in 2025. Only eight defenses have yielded more fantasy points per touch. There's boom potential based on his style of play as the Falcons have allowed a WR touchdown grab every 12.6 catches (9th-highest rate).

WR Christian Watson, Green Bay Packers vs. Philadelphia Eagles

Watson barely has been back on the field after being cleared from last year's knee reconstruction just two games ago, and the Packers absolutely will need him to ramp up his snap count this week. Green Bay lost TE Tucker Kraft and is possibly down three of its top five receivers vs. Philadelphia. The Eagles have enough firepower to force Jordan Love into a pass-heavy script, which favors Watson seeing at least a half-dozen targets. He's a WR3 or flex.

WR Darius Slayton, New York Giants at Chicago Bears

Chicago has allowed 37.1 PPR per game to wide receivers this year, and no team has permitted more touchdowns at a higher clip (every 6.5 catches). Slayton offers a respectable downfield weapon from your WR3 or flex spot, and his recent uptick in work (89% Week 9 snap count) helps mitigate risk typically associated with vertical wideouts.

TE Colston Loveland, Chicago Bears vs. New York Giants

The rookie’s target share surged in Week 9, and he should again be a focal point. Cole Kmet appears poised to return from a concussion, which adds some volatility, but Loveland was drafted in Round 1 for a reason, and he showed why last week. New York’s defense of tight ends has struggled over the last month, which helps keeping Loveland in play for another hot-hand scenario.

D/ST Jacksonville Jaguars at Houston Texans

With C.J. Stroud (concussion) sitting, the Jaguars become a plug-and-play streaming option against backup QB Davis Mills. While Houston's line has surrendered a lukewarm 2.4 sacks per game, Jacksonville’s pass rush vs. a reserve quarterback tilts this in your favor. There is a bonus if your league rewards for keeping points against low, too. The defensive team pool hasn't any significant woes to navigate this week, so there may be no pressing need to start the Jags.