Week 16 Predictions: Can the 49ers Overcome the Dolphins?

The Miami Dolphins will host the San Francisco 49ers at Hard Rock Stadium in Miami Gardens, Florida, on Sunday, December 22, at 1:25 p.m. PT. The Dolphins enter the game as slight favorites, with a one-point edge according to the latest odds.

Each week, 49ers Webzone staff members take part in the NFL Pick 'Em contest, predicting the winners of every NFL game. For Week 16, five out of seven participating staff members have picked the 49ers to defeat the Dolphins.

Among the fans participating in the NFL Pick 'Em contest, 67 percent are backing a 49ers victory, based on the latest poll results.

Most One-Sided Matchup: Patriots at Bills

The most lopsided prediction for Week 16 is Sunday's clash between the New England Patriots and the Buffalo Bills. An overwhelming 100 percent of fans are confident the Bills will secure the win. Buffalo is currently a 14-point favorite heading into the contest.

Most Competitive Matchup: Jaguars at Raiders

The tightest matchup of the week is Sunday's game between the Jacksonville Jaguars and the Las Vegas Raiders. In a near-even split, 54 percent of participants are picking the Jaguars to come out on top.

Week 16 NFL Matchups

Below is a breakdown of all 15 matchups for the upcoming slate of NFL games.