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Four college football teams on upset alert in Week 1
Penn State Nittany Lions head coach James Franklin. Matthew O'Haren-USA TODAY Sports

Four college football teams on upset alert in Week 1

After the Week 0 appetizer, college football delivers the Week 1 main course on Saturday. The schedule, which features mostly non-conference games, could produce several upsets. 

Here are teams favored by seven points or more that could lose their openers. (All lines from DraftKings as of Friday afternoon.)

Penn State at West Virginia (+7.5) 

In their home opener last season, Penn State beat West Virginia convincingly 38-15. In Week 1 this season, the Nittany Lions play in Morgantown, where they will face a hostile, alum Pat McAfee-fueled crowd.

The Mountaineers have lost their past three openers, but with star running back Jahiem White (7.7 per carry last season) healthy, WVU has a good chance to pull an upset.

New Penn State offensive coordinator Andy Kotelnicki must fix QB Drew Allar (59.9% completion percentage in 2023), who struggled in losses last season to Michigan and Ohio State.

Expect the Nittany Lions to struggle on offense early, giving West Virginia an opening.

Virginia Tech at Vanderbilt (+13.5)

In the preseason, media picked Virginia Tech to finish sixth in the 17-team ACC.  Meanwhile, Vanderbilt, the punching bag of the SEC, quietly had a solid offseason, luring the 39th-best recruiting class, per On3.com. 

The Commodores will probably have a new QB in New Mexico State transfer Diego Pavia, a dual-threat weapon who threw for 2,963 yards and rushed for 923 more last season. He is expected to be the starter, per The Tennessean.

"When you look at the young man (Pavia) and the quarterbacks they have on their roster, I have a tremendous amount of respect for them,” Virginia Tech defensive coordinator Chris Marve said, per On3.com.

Vanderbilt played Georgia fairly close last season before falling at home to the powerhouse Bulldogs 37-20. Tech isn't in Georgia's league. Expect the Commodores to at the very least cover the spread.

Hawaii (+14) at UCLA

Hawaii, which opened its season with a 35-14 win over Delaware State, takes on a UCLA team with a new, first-time head coach in DeShaun Foster and many new players. Foster expects to have jitters.

“I’m sure I’ll have them Friday night, the night before, or it might even happen as I’m running out before kickoff," he told Ben Bolch of the Los Angeles Times. If he does, what about his team?

A defense that returns only two starters looks like the Achilles' heel for the Bruins, who finished 8-5 last season under Chip Kelly, now Ohio State offensive coordinator.

UCLA drew more than 10,000 fans for its spring game, perhaps an indication of stronger interest from its fan base. But the Rose Bowl probably won't be over half-full for a game against an unheralded opponent. This has upset written all over it.

Wyoming (+7) at Arizona State

In its first game in the Big 12, Arizona State welcomes Wyoming to Tempe, where the Wildcats finished 2-6 last season. In 2023, the 3-9 Sun Devils failed to score more than 23 points in five of their last six games. 

In going 9-4 in 2023, the Cowboys played fairly well against Big 12 foes Texas (a 31-10 loss) and Texas Tech (35-33 win).

The key to an upset could be Wyoming's running game, which should be better behind a much improved offensive line. 

Jordan Merritt

Jordan Merritt is a UK native who is a passionate sports fan. He follows the NFL, college football, soccer, and many others. He is a freelance writer who has an unhealthy obsession with fantasy sports. You can find him on x @jordm87 discussing transfers for his fantasy soccer teams. 

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