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PRO insights reveal a sneaky sharp way to bet 49ers vs. Seahawks picks for "Thursday Night Football."
The Seattle Seahawks (3-2) are gearing up to host the San Francisco 49ers (2-3) in what promises to be an electrifying "Thursday Night Football" matchup at Lumen Field. The NFC West clash features star power on both sides.
The Seahawks boast quarterback Geno Smith and wide receiver DK Metcalf, while the 49ers look to wide receiver Deebo Samuel and linebacker Fred Warner to get back on track. Both teams are coming off losses, adding a layer of urgency to Thursday’s NFL Week 6 contest. Currently, the 49ers are road favorites, with the over/under set at 49.5 points.
49ers vs. Seahawks Odds, Picks, Predictions
- 49ers vs. Seahawks spread: 49ers -3.5
- 49ers vs. Seahawks over/under: 49.5
- 49ers vs. Seahawks moneyline: 49ers -190, Seahawks +155
Spread
The 49ers are favored by 3.5 points.
Over/Under
The over/under is set at 49.5 points, up from 47.5.
Moneyline
The moneyline is 49ers -190, Seahawks +155.
Point Spread
The point spread in PRO is drawing notable attention, with sharp action indicating a significant amount of professional money backing the 49ers.
Additionally, San Francisco is garnering 75% of the total money and 62% of the bets in the spread market, underscoring its position as the favored pick. However, our PRO Projections consider the spread with Seattle as only a +2.6 favorite, indicating a possible edge in Seattle’s favor if the market overrates the 49ers.
Total
For the total, the under appears to be the savvy lean, with our PRO Projections suggesting the total should be closer to the open (47.5 points).
Odds to Win
On the moneyline, the PRO Projections suggest Seattle’s odds should be closer to +134, presenting nuance against the market’s current +157.
Our PRO Picks
Seahawks running back Zach Charbonnet helped cash a +650 prop a few weeks ago. One of Charbonnet’s props for Thursday Night Football is the best way to bet the game.
Starting running back Kenneth Walker should see regular time. Charbonnet’s rushing yards over/under is 12.5. That’s a bit too low.
Our PRO Projections peg the backup tailback for closer to 17, resulting in a solid 8.1% edge. Take the over on Charbonnet’s rushing yards.
Seahawks vs. 49ers Weather
Check out Yardbarker's betting hub for odds, picks, predictions and analysis — and start winning TODAY!
Seahawks vs. 49ers Betting Trends
Here are some neat trends courtesy of betting researcher Evan Abrams:
➤Geno Smith is 11-17-2 ATS as a favorite in his career and 22-18-2 ATS as an underdog.
➤Brock Purdy is 17-15 ATS in his NFL career. When he’s favored by 4 points or more, he’s 9-13 ATS, when he’s favored by 3.5 pts or less or an underdog, Purdy is 8-2 ATS.
Our PRO signals flag far more great picks than our staff could author each day — that’s where Action AI comes in. Using generative AI, signals that hit a high grade threshold are written up into articles that are then vetted and edited by a human to help us get you all the sharp action. Read more about how it works here.
Check out Yardbarker's betting hub for odds, picks, predictions and analysis — and start winning TODAY!
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