Watch: Lions WR Amon-Ra St. Brown scores 66-yard TD vs. Bills

The TD catch put St. Brown at 155 yards receiving at the time. Surprisingly, this marks the first time St. Brown has eclipsed 100 yards and recorded a TD in a game since Nov. 17 against the Jacksonville Jaguars.

While the TD strike to St. Brown was Goff's third of the game through the air, Detroit's lack of a run game and poor defensive performance have plagued them throughout the game.

The Lions have trailed by multiple scores for most of the game and have been unable to find any answer to the Buffalo offense.

The Lions answered once again with a 12-yard TD pass from Goff to RB Jahmyr Gibbs with 12:00 left, giving Goff his fourth TD pass of the game. However, the Bills took advantage of a failed onside kick attempt and scored one play later to extend their lead to 45-28.