Week 16 worst QB performances: Kenny Pickett shows Eagles how much they need Jalen Hurts

The second pick-six came on a deflected pass at the line of scrimmage and killed any hope for the Giants (2-13) to mount a comeback.

This season, Lock is 68-of-129 (52.7 percent) for 624 yards (4.8 yards per attempt), one touchdown and four interceptions. It might be a while until another team trusts him to run a first-team offense.

Jets quarterback Aaron Rodgers

Rodgers' day went downhill after leading the Jets on a 99-yard opening drive touchdown.

He only managed one field goal the rest of the game while turning the ball over on downs twice with fourth-down incompletions and losing a fumble in a 9-9 game that led to the Rams taking a 16-9 lead.

Rodgers sailed a pass intended for wide receiver Davante Adams on the play directly before his game-altering turnover.

On his fumble, Rodgers was indecisive in the pocket. Los Angeles did a good job of eliminating New York's underneath routes on the third-down play, but Rodgers made matters worse by not securing the football when scrambling.

The Jets were rightfully optimistic when trading for Rodgers, believing that adding a four-time MVP to an already strong defense would catapult them to the playoffs.

On Sunday, New York's defense held up its end of the bargain, limiting the Rams (9-6) to 242 total yards, including 110 passing. Rodgers and the offense let the Jets (4-11) down.

Cardinals quarterback Kyler Murray

The Cardinals (7-8) were officially eliminated from playoff contention with their 36-30 overtime loss to the Panthers.

Making matters worse, Murray was thoroughly outplayed by embattled Panthers quarterback Bryce Young, whose comeback from an early-season benching has become one of the league's best stories.

Murray was 20-of-32 for 202 yards (6.3 yards per attempt), one touchdown and one interception. He was also sacked three times, losing 26 yards, and fumbled a snap, giving Carolina possession at Arizona's 30-yard line.

His fourth-quarter interception came on an ugly deep throw on a third-and-12.

Murray has tapered off following the Cardinals' 6-4 start. During their current 1-4 stretch, 2019's No. 1 overall pick has gone 123-of-182 (67.6 percent) for 1,230 yards (6.8 yards per attempt), four touchdowns and six interceptions.

49ers quarterback Brock Purdy

Sunday was a bad day for Purdy. Not only were the 49ers (6-9) officially eliminated from playoff contention before the kickoff of their 29-17 loss to the Dolphins (7-8), but Purdy sealed San Francisco's first losing season since 2020 with a fourth-quarter interception down five, 22-17.

Purdy's numbers overall were fine — he was 26-of-40 for 313 yards (7.8 yards per attempt), two touchdowns and an interception. But Week 16 underscored how poorly things have gone for the third-year quarterback as he prepares to negotiate his second Niners contract.