Typically, a No. 11-seed losing to a No. 6-seed isn't an unusual thing to see in the NCAA Tournament.
However, on Friday, No. 11-seed Xavier's 86-73 loss to No. 6-seed Illinois marked an incredibly rare event in the tournament's history.
The Musketeers were the last team that advanced out of the First Four play-in games in Dayton, Ohio remaining in the tournament. No. 11-seed North Carolina and No. 16-seeds Mount St. Mary's and Alabama State were all defeated ahead of Friday night's contest.
Upon Xavier's loss, it became the first time since 2019 no team from the First Four had won in the first round.
In fact, it's only the second time since the First Four was introduced into March Madness in 2011 that no team emerging victorious from Dayton advanced to the Round of 32.
The most notable teams to make deep runs after winning their respective play-in games were VCU (2011 Final Four) and UCLA (2021 Final Four). Both were the lowest seeds to ever reach the national semifinals.
UCLA is the second First Four team to advance to the Elite Eight, joining the 2011 VCU team that reached the Final Four.
— ESPN (@espn) March 29, 2021
(h/t @DavidWorlock) pic.twitter.com/1VpaMeZ2Iz
Fairleigh Dickinson became the first No. 16-seed to win a First Four game and then go on to defeat a No. 1 seed (Purdue) in 2023.
The 2025 tournament won't be short of Cinderella candidates, though.
Five double-digit seeds advanced out of the first round, three of them in the South Region alone.
No. 12-seed Colorado State upset No. 5-seed Memphis, 78-70, for its first March Madness win since 2013 on Friday.
And No. 10-seed New Mexico took down No. 7-seed Marquette, 75-66, to advance to its first Round of 32 since 2012.
Both join Thursday victors No. 12-seed McNeese State, which defeated No. 5-seed Clemson, 69-67, No. 11-seed Drake, which beat No. 6-seed Missouri, 67-57 and No. 10-seed Arkansas, which knocked off No. 7-seed Kansas, 79-72, in the second round.
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