The San Francisco 49ers are one of a few teams that have been bitten especially hard by the injury bug this season.
However, they’ve avoided the injury to their star running back that had everyone worried to start the year, but in a crucial divisional matchup on "Thursday Night Football," the 49ers’ injury report ruled out five players, including the starting quarterback and three wide receivers.
San Francisco was able to pull out a victory despite the team that’s taken so many hits thus far taking a few more in Los Angeles. The successful trip saw injuries suffered by defensive tackles Kalia Davis, Yetur Gross-Matos and rookie Alfred Collins, as well as rookie cornerback Upton Stout, according to Nick Wagoner of ESPN.
The only one who appears to have gotten off easy is Stout, who avoided a high ankle sprain and just suffered a regular ankle sprain.
#49ers coach Kyle Shanahan on injuries:
— Nick Wagoner (@nwagoner) October 3, 2025
CB Upton Stout has an ankle sprain. Not a high ankle. He'll be day to day.
DT Kalia Davis having surgery on broken hand this afternoon.
DT Yetur Gross-Matos will miss some time with a hamstring strain.
DT Alfred Collins has a sprained…
Davis, on the other hand, will require surgery to repair a broken bone in his hand. Per Ian Rapoport of NFL Network, the procedure was scheduled to take place Friday. There’s some thought that Davis could potentially miss as few as two games, as well. As a defensive lineman, Davis doesn’t have too much use for the gripping mechanic of that appendage, and some expect him to return to play with a club cast on his hand.
#49ers DT Kalia Davis, part of an unheralded SF defensive front that continues to get pressure, will undergo surgery today to repair a broken hand, sources say.
— Ian Rapoport (@RapSheet) October 3, 2025
Davis could miss as few as two games, and he's expected to return with a club. pic.twitter.com/XLdMro0Yi7
Gross-Matos had just come off his only full practice of the week as he worked his way back from a knee injury. While the knee seemingly held up Thursday night, Gross-Matos is now set to miss time with a hamstring strain, which could mean a multi-week absence. The rookie, Collins, suffered a sprained knee. With the "Thursday Night Football" matchup allowing for a bit more time to recover before their next game, Collins may stand a chance to not miss time, depending on the severity of the sprain.
Lastly, while we knew that star tight end George Kittle would be eligible to return from injured reserve in Week 6 after being placed on list after the season opener, we’ve finally received some insight on a more specific timeline. Per Vic Tafur of The Athletic, head coach Kyle Shanahan informed the media that Kittle likely will not be able to make it back until at least Week 7. At best, this will limit the veteran in-line pass catcher to a five-game absence.
Shanahan said George Kittle likely not back until Week 7.
— Vic Tafur (@VicTafur) October 3, 2025
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