Deebo Samuel expected to miss time with hamstring injury

San Francisco 49ers wide receiver Deebo Samuel Sr. IMAGN IMAGES via Reuters Connect

49ers WR Deebo Samuel expected to miss time with hamstring injury

By Andrew Wright | Last updated Oct 12, 2026 4:13 PM ET

Each and every season, the San Francisco 49ers seem to deal with more injuries than any other team in the NFL.

That trend has continued this season, with the San Francisco wide receiver room constantly suffering injuries week after week. That situation further played out Sunday with Deebo Samuel going down with a hamstring injury, and the severity and timeline of his injury have now been revealed.

Deebo Samuel is expected to miss some time

According to 49ers head coach Kyle Shanahan, Samuel is expected to miss 'at least a couple of weeks' with the hamstring injury he suffered in Sunday's 32-29 win over the Seattle Seahawks.

Samuel is just the latest San Francisco receiver who will miss time due to injury, joining De'Zhaun Stribling, Christian Kirk, Ricky Pearsall and Demarcus Robinson.

49ers HC Kyle Shanahan told reporters that WR Deebo Samuel is expected to miss “at least a couple of weeks” with the hamstring injury he suffered Sunday in Seattle. pic.twitter.com/QcKufahl79
— Adam Schefter (@AdamSchefter) October 12, 2026

Christian McCaffrey may benefit from all the injuries

So far this season, the use of running back Christian McCaffrey has been lower than in previous years. McCaffrey ranks 23rd in carries (61) and 17th in rushing yards (286). San Francisco has seemed hesitant to heavily involve McCaffrey in the offense, but that could certainly change soon with all the injuries taking place.

McCaffrey's season high in carries so far is 15, a number he surpassed in 12 of 17 regular-season games last year. Even with the 49ers having success without McCaffrey running well, it may be time to make that a focal point of the offense while the receiver room gets healthy.

San Francisco will be extremely dangerous at full strength

Speaking of getting healthy, the San Francisco offense could be nearly impossible to stop when it gets back to full health. It's already been tough to stop through five weeks, and that is with consistent injuries affecting the depth and rotations that Shanahan is able to use.

The 49ers have started 5-0 under Shanahan (2019, 2023), and they reached the Super Bowl in both of those seasons; if they are able to get back to full strength, history may very well repeat itself in 2026.

Andrew Wright

Andrew "Dew" Wright graduated from Charleston Southern University with a degree in Communication Studies. He is a lifelong Chicago Cubs and Washington Commanders fan.

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