NFL Week 10 prime-time predictions: Joe Burrow bolsters MVP case, Cam Skattebo heats up

Cincinnati Bengals quarterback Joe Burrow. USA TODAY Network via Reuters Connect

NFL Week 10 prime-time predictions: Joe Burrow bolsters MVP case, Cam Skattebo heats up

By Clark Dalton | Last updated Nov 11, 2026 12:55 PM ET

Each week, Yardbarker previews prime-time NFL games on Thursday, Sunday and Monday nights, predicting the result of each. Here are our Week 10 picks.

Thursday night: Washington Commanders (2-5-1) at New York Giants (5-2-1) (Prime Video, 8:15 p.m. ET)

Giants quarterback J.J. McCarthy suffered a hip injury in a 19-11 Week 9 win over the Philadelphia Eagles, but head coach John Harbaugh indicated he'll be ready to go against Washington. Running back Cam Skattebo (hamstring) is also expected to play in Week 10.

Skattebo — who has surpassed 100 rushing yards once in seven games — is aiming to prove he can be one of the "most dangerous backs in the league" after the Giants almost traded for Indianapolis Colts RB Jonathan Taylor before Tuesday's trade deadline. New York reportedly offered a second- and fifth-rounder for Taylor but stopped negotiating with Indianapolis after it rejected the package. Afterward, the Giants reportedly called the Atlanta Falcons on standout RB Bijan Robinson, but that went nowhere.

Skattebo may prove the Giants made the right decision to let him remain RB1 in Week 10. The Commanders run defense has regressed since star defensive tackle Daron Payne (foot) was ruled out for the rest of the season. The unit has allowed 107.5 rushing yards per game over its past two games, up from 100.5 in its first six with Payne.

Prediction: Giants, 27-20

Sunday night: Pittsburgh Steelers (6-2) at Cincinnati Bengals (6-2) (NBC, 8:20 p.m. ET)

Can anyone stop Bengals QB Joe Burrow?

Entering Week 10, Burrow leads the NFL in TDs with 26 (23 passing and three rushing), via Pro Football Focus. He has had four or more TDs in his last four games.

Joe Burrow and Josh Allen have already had their bye weeks pic.twitter.com/MAd50lh04d
— PFF (@PFF) November 10, 2026

That has made the Bengals star the midseason MVP in the eyes of many, including the reigning league MVP. Los Angeles Rams QB Matthew Stafford said on this week's "Let's Go!" podcast that he would give Burrow the award at the midpoint of the season.

On Tuesday, LB Patrick Queen hinted the Steelers plan to use more disguised coverages to confuse Burrow, but they may not work against the QB he deems "the best in the league."

Prediction: Bengals, 30-27

Monday night: Los Angeles Chargers (0-8) at Baltimore Ravens (4-5) (ABC/ESPN, 8:15 p.m. ET)

NFL schedule makers probably regret picking this matchup for this slot.

Chargers QB Justin Herbert and new offensive coordinator Mike McDaniel have been a horrible football marriage. Through eight starts, seventh-year veteran Herbert has posted career worsts in completion percentage (61.3 percent), passing yards per game (198.9) and passer rating (70.4). Not to mention, he's tied for the league lead in interceptions (11).

Ravens QBs Lamar Jackson (thumb) and Tyler Huntley (toe), meanwhile, are on injured reserve. (Huntley is expected to miss the rest of the season.) Undrafted rookie Joe Fagnano replaced them in a 33-10 Week 9 loss to the Jacksonville Jaguars (6-2) but isn't expected to start after Baltimore acquired QB Jacoby Brissett from the Arizona Cardinals before the deadline. He posted a below-average 79.7 passer rating in eight games for Arizona.

At least Baltimore can fall back on RB Derrick Henry (689 rushing yards, No. 7 in NFL). The same can't be said for the Chargers. RB Omarion Hampton leads the team in rushing yards (369, tied for No. 25 in NFL).

Prediction: Ravens, 19-16

Clark Dalton

Clark Dalton is a 2022 journalism graduate of the University of Texas at Austin. He gained experience in sports media over the past seven years — from live broadcasting and creating short films to podcasting and producing. In college, he wrote for The Daily Texan. He loves sports and enjoys hiking, kayaking and camping.

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