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ATP US Open Best Bets Including Sinner vs Popyrin
Main photo credit: Mike Frey-Imagn Images

ATP US Open 1/32-Finals

Brooksby – Cobolli: 28.08.2025 18:30 CEST
H2H: 1-0

Jenson Brooksby has won three of his last five matches. The last match he played before the US Open was in Cincinnati, when he lost to Khachanov in the third round. This will be his fifth appearance in New York. He has never made it past the fourth round here. In the opening round, Brooksby defeated Vukic in five tight sets.

Flavio Cobolli has won three of his last five matches. This week in New York, the Italian won the opening round against Passaro in five tight sets. After spending almost four hours on the court, Cobolli played his best tennis in the deciding set.

Best Bet to Make

According to the bookies, this will be an almost 50-50 matchup, but we disagree. Cobolli enjoys playing at the Grand Slam level. This is his breakthrough season. On the other hand, Brooksby had a rough opening match and will be tired coming into this match. We expect Cobolli to be a better player tonight.

That being said, Cobolli winning is a value bet.

Value bet/ the best odds: Flavio Cobolli winning @1.57 @bet365

Khachanov – Majchrzak: 28.08.2025 18:30 CEST
H2H: 4-0

Karen Khachanov has won three of his last five matches. In the past two appearances, Khachanov lost in the opening round. His best result was in 2022, when he reached the semifinals. This week, Khachanov won against Basavareddy in four sets. After losing the opening set 6-7, Khachanov turned the match quickly around.

Kamil Majchrzak has won four of his last five matches. This week in New York, the Pole had a favourable opening round draw. In the first round, Majchrzak defeated Dellien in four sets.

Best Bet to Make

According to the bookies, Khachanov is the favourite in this matchup, and we agree. He is in solid form and enjoys playing on fast courts. The Russian leads 4-0 in head-to-head meetings, whilst losing only one set against Majchrzak in those four meetings. We expect Khachanov to win easily tonight.

That being said, Khachanov covering the games handicap is a value bet.

Value bet/ the best odds: Karen Khachanov -5.5 games handicap @1.80 @bet365

Sinner – Popyrin: 28.08.2025 19:00 CEST
H2H: 0-1

Jannik Sinner has won four of his last five matches. The Italian is the defending champion in New York. Last season, Sinner defeated Fritz in the final in straight sets. This week, Sinner defeated Kopriva in straight sets comfortably. He saved two breakpoints.

Alexei Popyrin has won three of his last five matches. This week at the US Open, Popyrin defeated Ruusuvuori in straight sets in the opening round. The Australian trailed 1-3 in the third set, but turned it around.

Best Bet to Make

According to the bookies, Sinner is the heavy favourite in this matchup, and we partially agree. However, Popyrin has a powerful serve and enjoys playing at Grand Slam events, which are often packed with crowds. We expect him to keep this match close.

That being said, Popyrin covering the games handicap is a value bet.

Value bet/ the best odds: Alexei Popyrin +8.5 games handicap @1.73 @bet365

This article first appeared on Last Word On Sports and was syndicated with permission.

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