ESPN's FPI Predicts Outcome of LSU Football vs. Ole Miss Rebels Week 5 SEC Matchup

Originally posted on LSU Tigers on SI | By Zack Nagy | Last updated Sep 23, 2025 4:45 PM ET

No. 4 LSU (4-0, 2-0 SEC) will travel to the Magnolia State in Week 5 for an SEC showdown against Lane Kiffin and the No. 13 ranked Ole Miss Rebels.

After capturing four consecutive wins to open the season, including victories over Clemson and Florida, the Bayou Bengals will look to keep their 2025 record unblemished.

Lane Kiffin and the Ole Miss Rebels will once again present a unique challenge for Kelly and Co. with their up-tempo offense clicking on all cylinders out the gate this season.

"Lane does a great job adapting to what's going on in the game itself," Kelly said of Kiffin as a playcaller.

"I think, more than anything else, you can plan for things to happen, but then you have to be able to prepare for what's the next step, and he's obviously very experienced at what he does. During the game, he can adjust as he sees that he needs to."

The Game Information: Week 5 Edition

Matchup : Ole Miss Rebels vs. LSU Tigers
Kickoff Time: 2:30 p.m. CT
Venue: Vaught Hemingway Stadium - Oxford (Miss.)
TV Channel: ABC
Radio: LSU Sports Radio Network
LSU Tigers Record: 4-0 (1-0 SEC)
Ole Miss Rebels Record: 4-0 (2-0 SEC)

Odds, Spread and Total: Week 5 Edition

Odds via DraftKings Sportsbook

Spread

LSU: +1.5 (-115)
Ole Miss: -1.5 (-105)

Moneyline

LSU: -105
Ole Miss: -115

Total

Over: 54.5 (-112)
Under 54.5 (-108)

The Ole Miss Rebels will enter the Week 5 clash as 1.5-point favorites, according to DraftKings Sportsbook.

The ESPN Football Power Index Pick: LSU Falls in Oxford

Brian Kelly and the LSU Tigers will enter Saturday's showdown against the Ole Miss Rebels with a with a 26.7 percent chance of taking home a victory.

The ESPN FPI favors the Rebels in this one with Kelly and Co. entering the clash as the underdogs.

The ESPN SP+ Prediction: What The Analytics Say

According to Bill Connelly's SP+ computer model, the LSU Tigers have a 36 percent chance of walking out of Vaught Hemingay Stadium with a victory over the Ole Miss Rebels.

The expert computer model is giving Ole Miss the edge with a final score prediction of 29-23 in the Week 5 matchup with the Rebels predicted to earn the win.

No. 4 LSU and No. 13 Ole Miss will kickoff at 2:30 p.m. CT on ABC with all eyes set to be on the Top-15 Southeastern Conference matchup between a pair of unbeaten programs.

This article first appeared on LSU Tigers on SI and was syndicated with permission.

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