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Michigan vs Oklahoma Prediction: A College Football Playoff Battle in Week 2
© Kevin Jairaj-Imagn Images

Each superpower program had enough time to get back up to speed. Grace period over - be really great at college football again, Michigan and Oklahoma.

The Wolverines had an acceptable down year after all the controversy and all the craziness of the national championship season. But when you end with wins over Ohio State and Alabama, things aren’t so bad.

Now it’s time to show that they’re back in the mix for things that matter. That goes triple for Oklahoma.

Michigan vs Oklahoma Preview: Why This Feels Like a Playoff In September

The Brent Venables era hasn’t been able to get going, but he’s got a team loaded with talent, and this is the chance to show it off. However …

Auburn, Texas, at South Carolina, Ole Miss, at Tennessee, at Alabama, Missouri, LSU. All of THAT is still on the Sooner slate, so lose this, and that’s all but it for a team good enough to push for the College Football Playoff.

At Nebraska, at USC, at Michigan State, Ohio State. That’s it for the dangerous games left for Michigan, so win this, and there’s a real shot to be something special this year.

Michigan vs Oklahoma: How To Watch

Date: Saturday, September 6, 2025
Game Time: 7:30 PM ET
TV: ABC
Location: Memorial Stadium, Norman, OK
@PeteFiutak

America, Meet Michigan Wolverines Quarterback Bryce Underwood

It was only a paycheck game against New Mexico in a 34-17 win, but true freshman Bryce Underwood completed 21-of-31 passes for 251 yards and a touchdown. No big whoop, right?

Michigan had just two 200-yard passing days last year, and the high mark was 208.

The Wolverine offense has rediscovered the forward pass, transfer running back Justice Haynes is coming off a monster 159-yard, three-touchdown day, and forget the issues with the Lobo passing game, the defense was and will be the Michigan defense again.

The D didn’t turn it loose on New Mexico, but here comes the pass rush on …

America, Meet Oklahoma Sooners Quarterback John Mateer

Mateer was arguably the best player in the transfer portal this offseason. He can run, make big plays down the field, and he showed it all off in the 35-3 win over Illinois State in the opener.

It was Week 1, so things weren’t always smooth, but Mateer came up big, hitting 30-of-37 passes for 392 yards and three scores, and he ran for a touchdown. Making life easier is a Sooner receiving corps with real, live wideouts who are healthy enough to play - that wasn’t the case last year.

Like Michigan, Oklahoma didn’t seem to unleash all of its defensive playbook, so …

Oklahoma At Home Will Mean Everything

It won’t exactly have the same nuclear energy burst like Florida State showed in its win over Alabama, or what Miami was like in the big victory over Notre Dame, but after two losing seasons in three years, this is a program and a fan base about to burst.

Underwood will be great, but he’ll have a few freshman moments on the road to screw things up a bit. Both quarterbacks will be good, but both defenses will be better.

Oklahoma’s defense will look and play like a Brent Venables defense that was waiting for this.

Michigan vs Oklahoma Prediction, Betting Lines

Oklahoma 24, Michigan 20
Line: Oklahoma -5.5, o/u: 45.5
ATS Confidence out of 5: 2
Must See Rating: 5

- CFN Week 2 Rankings | Bowl Projections
- Predicting Every Game For the 2025 Season
- Hot Seat Coaches | Grading the New QBs

Consensus Line from BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

This article first appeared on College Football News and was syndicated with permission.

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