No. 10 Clemson vs. Louisville prediction, pick, odds: Tigers look to peak late

OddsChecker prediction, pick, odds

The Clemson Tigers host ACC rivals Louisville Saturday afternoon. The Tigers are coming off their first loss of the season. Can they bounce back at home, where they dominate? Handicapper Matt McCuen is here with his best bet for today's ACC clash.

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The Tigers have made the CFP in six of the past eight seasons. They have a 38-game home winning streak and have never lost to Louisville in seven previous meetings.

"Every goal we have is intact," Clemson coach Dabo Swinney said. "Every time we've hit all those goals, we've either won the national championship or had an amazing year. We won the opener, we can win the division, we can still win the state championship, we can still win this league, and we can still win the closer. There is only one thing off the table for us and that's going undefeated."

Swinney remains optimistic and later pointed out that Clemson won 14 consecutive games following its previous defeat.

But the Tigers lost to a three-loss Fighting Irish team and have no games left against ranked opponents to help bolster their playoff resume.

The alarming part for Swinney was the way Clemson was dominated by Notre Dame in its worst loss to an unranked opponent in 11 years.

Notre Dame blocked a punt and returned it for a touchdown and returned an interception by DJ Uiagalelei 96 yards for a touchdown to build a 28-0 lead in the fourth quarter.

"Physically (we) got our butt kicked. Real simple," Swinney said. "We did a lot of technical things wrong, too. Momentum, turnovers, blocked punt. It's hard to turn that on the road. Good news is we know we're better than that."

Swinney said wide receiver Beaux Collins separated his shoulder last week and won't play against Louisville.

Louisville (6-3, 3-3) is on a four-game winning streak that includes wins over a ranked Wake Forest team and a James Madison team that was ranked earlier this season.

The Cardinals are playing some of their best football of the season and showed it in the 34-10 victory over the Dukes. Quarterback Malik Cunningham was sharp, completing 14 of 20 passes for 223 yards and three touchdowns.

Louisville's defense also held James Madison to 193 total yards.

"I think once you get after the first part of the season, you kind of get a good identity of your team," Louisville coach Scott Satterfield said. "You kind of know where your strengths and weaknesses are after the first four or five games. We were inconsistent early on playing, and I think over the last four games, we've really found some consistency."

The Cardinals amassed 244 yards on the ground against the top-ranked rushing defense in the FBS in terms of yards per carry (2.47) led by Tiyon Evans (10 carries, 126 yards, TD) and Jawhar Jordan (17 carries, 117 yards).

Clemson is ranked 20th in the nation in rushing yards allowed per carry and allows 6.32 passing yards per attempt.

"You look at their team defensively, they're still outstanding on the strength of their team up front on the defensive line, two deep," Satterfield said. "They're all really good players, high draft pick players."