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Ohio State vs Grambling State Prediction: The No. 1 Buckeyes Get a Tune-Up
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Ohio State is back to being the nation’s No. 1 team - at least according to the latest polls after its tough 14-7 win over Texas - and Grambling State has a national stage in a showcase moment against the defending FBS national champion.

The Tigers are coming off a 55-7 crushing of Langston, and now they have to deal with the Buckeyes.

Ohio State gets to work on the offense a bit, should open it up a bit more than it did against Texas, and then it’s on to Ohio before starting the Big Ten season at Washington.

Ohio State vs Grambling State Preview: The Buckeyes Get the O Going

Ohio State vs Grambling State: How To Watch

Date: Saturday, September 6, 2025
Game Time: 3:30 PM ET
TV: BTN
Location: Ohio Stadium, Columbus, OH
@PeteFiutak

Grambling State Will Bring the Pressure

The Tigers were great at taking the ball away last season.

Few defenses in the FCS were stronger at getting into the backfield, forcing 26 on the year. It kept it all going to start the season, dominating against Langston with three takeaways, and getting into the backfield enough to hold the Lions to -32 rushing yards.

Ohio State’s offensive front shouldn’t have too many problems, but Grambling State’s pass rushers should provide a bit of a push.

Ohio State Will Get Jeremiah Smith the Ball

The Buckeyes should be able to move the ball however they want to, but first, they have to get 4 on the same page as 10.

The ground game will take over for most of the game, but over the first quarter or so, Julian Sayin’s job is to start pushing the ball down the field, especially to his main weapon.

Jeremiah Smith had a few drops against Texas, but he caught a game-high six passes for 43 yards. That was fine, but he wasn’t able to do anything big.

The Buckeyes didn't take any big chances as long as the defense was keeping Arch Manning and the Longhorn O in check. This week, Sayin will get his chance to start throwing.

Ohio State Will End This Fast, But Will There Be a Letdown?

Yes, this will be a blowout, and yes, the Ohio State defense can be a brick wall if it goes full throttle for a full four quarters.

Grambling State will have a few good drives, but the production won’t be nearly enough to overcome a huge first quarter by the Buckeye offense that opens it up right away.

Ohio State vs Grambling State Prediction, Betting Lines

Ohio State 55, Grambling State 0
Line: COMING, o/u: COMING
ATS Confidence out of 5: COMING
Must See Rating: 2

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Consensus Line from BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

This article first appeared on College Football News and was syndicated with permission.

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