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Oklahoma State vs Arizona Prediction: The Game the Wildcats Must Win
© Aryanna Frank-Imagn Images

Every college football team has to win every game. But there are some you really, really can't lose.

Oklahoma State really, really couldn't lose to Tulsa, it did, and now Mike Gundy has moved on to bigger and better things.

Arizona can't lose to Oklahoma State.

It's not like second-year head coach Brent Brennan will be fired if the Cats blow this, but after getting crushed by Iowa State, and with BYU up next, if you can't beat this Cowboy team ...

Oklahoma State Cowboys vs Arizona Wildcats Preview

How To Watch Oklahoma State vs Arizona

Saturday, October 4, 2025
Game Time: 3:00 PM ET
TV: TNT
Location: Arizona Stadium, Tucson, AZ

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Why Oklahoma State Will Win

Oklahoma State does have positive parts.

The running game hasn't been awful. It hasn't been dominant, but it was good against both Tulsa and Baylor when the offense gave it a shot. For what it's worth, as bad as the last two games have been, the attack hasn't turned the ball over.

Arizona's offense is a bit hit-or-miss. It was fine against Hawaii and Weber State, but it wasn't nearly as sharp when it stepped up in weight class against Kansas State and Iowa State.

Why Arizona Will Win

Oklahoma State has zero mojo.

It's trying, and the effort is there, but there's just no execution in big moments to turn a corner.

Both sides of the ball are awful on third downs. The pass rush isn't even close, and go ahead and run the ball as much as you'd like against this front.

Arizona was able to run well against Kansas State and threw well at times in the loss to Iowa State.

Arizona Needs an Easy Win

And it'll get it.

Oklahoma State will keep trying. It'll put up a few points, and it'll have a few nice moments when it stops the Arizona attack, but the trickle will turn into an avalanche in the third quarter.

The lack of a Cowboy pass rush will prove deadly once Noah Fifita and the Arizona passing game settle in.

Oklahoma State vs Arizona Prediction, Betting Lines

Arizona 40, Oklahoma State 16
Line: Arizona -20.5, o/u: 55.5
ATS Confidence out of 5: 3
Must See Rating: 2.5

Consensus Line from BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER. 

- CFP Top 12 & Projections

This article first appeared on College Football News and was syndicated with permission.

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