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South Carolina vs Kentucky Updated Betting Odds: Gamecocks Lead Shrinks
Sep 20, 2025; Columbia, Missouri, USA; South Carolina Gamecocks quarterback LaNorris Sellers (16) runs the ball against the Missouri Tigers during the second half of the game at Faurot Field at Memorial Stadium. Mandatory Credit: Denny Medley-Imagn Images Denny Medley-Imagn Images

An updated look at the betting odds for the South Carolina vs Kentucky matchup.

The South Carolina Gamecocks are getting ready for their third conference matchup of the season and are still hunting for their first win. They are fresh off of a road loss against Missouri but this weekend they are back at home to take on the Kentucky Wildcats.

If the Gamecocks want to get things back on track, this is a must-win game for them. The Wildcats have been struggling this season, however, they lost by just seven points against Ole Miss two weeks ago and they coming off a bye week for this game.

According to the betting odds, though, South Carolina will be in another close game this weekend

The Gamecocks are listed as a 5.5-point favorite against Kentucky, according to Fan Duel. The over/under for the game is listed at 46.5. The line initially started at 6.5 earlier in the week and has now closed to 5.5. Where this line closes before kickoff is something to keep an eye on.

South Carolina vs Kentucky Injury Report:

South Carolina:

  • Buddy Mack, Doubtful
  • Nolan Hay, Doubtful
  • Cason Henry, Doubtful
  • Gabriel Brownlow-Dindy, Doubtful
  • DQ Smith, Questionable
  • Judge Collier, Questionable

Kentucky:

  • Jamarion Wilcox, Out
  • Nic Smith, Out
  • David Washington Jr., Out
  • Elijah Brown, Out
  • Preston Browman, Out
  • Zach Calzada, Questionable
  • Aba Selm, Questionable
  • DJ Waller Jr., Doubtful

The last time these two teams faced, South Carolina walked out of Lexington with a convincing win. Shane Beamer and his program will be hoping to see similar results this weekend as they have gotten off to a rocky start through four weeks.

Kickoff for this game is set for 7:45 PM ET and will be broadcasted on SEC Network. The Gamecocks will then go on a bye week before they go on the road and play the LSU Tigers. A time has not yet been announced for that matchup and neither has a TV broadcast.

This article first appeared on South Carolina Gamecocks on SI and was syndicated with permission.

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