Three Saturday underdogs taking the most money to win in Week 2

Michigan is an underdog against Oklahoma according to the line makers, but the Wolverines travel to Norman as the higher-ranked team in the AP Top 25 poll. Following a season-opening win over New Mexico, Michigan is ranked at No. 15, while Oklahoma checks in three spots behind at No. 18.

Michigan-Oklahoma is the only game on the Week 2 schedule featuring two Top 25-ranked teams. The Sooners easily dispatched Illinois State in their season opener. Transfer quarterback John Mateer completed 30-of-37 passes for 392 yards and three touchdowns in the win, and is earning increasing Heisman Trophy consideration.

Michigan, however, is bringing in a true freshman quarterback making his first start on the road. Bryce Underwood had a fairly comfortable debut at Michigan Stadium last Saturday, but it will be a different atmosphere with a hostile Sooners crowd welcoming the Wolverines to Norman. This game opened at Oklahoma -1.5, but the line has moved to seeing the Sooners as 5.5-point favorites at several books.

Baylor, meanwhile, goes on the road to No. 17 SMU as just a 2.5-point underdog after losing their season opener to Auburn by a final of 38-24. Senior quarterback Sawyer Robertson threw for over 400 yards in that contest, but the Bears’ defense struggled to keep Auburn out of the end zone.

SMU actually dropped a spot in the AP Top 25 after a 42-13 win over FCS Foe East Texas A&M in their season opener. The Mustangs made the College Football Playoff last season in their first year as a member of the ACC. Rhett Lashlee’s squad is looking to build upon that success, but need to get by Saturday’s in-state foe first.

The third most-bet underdog heading into Week 2 of the college football season is Iowa facing in-state rival Iowa State for the Cy-Hawk Trophy . Following a 2-0 start to the 2025 season, Matt Campbell's Iowa State Cyclones are starting to receive increased talk as a sleeper contender for the College Football Playoffs.

Iowa would love to rain on the Iowa State parade, and is just a 3.5-point underdog going into Ames on Saturday. The Hawkeyes play tough defense for coordinator Phil Parker, but face an experienced Rocco Becht leading the Iowa State offense under center.

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