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USC vs Georgia Southern Prediction: Can the Trojans Keep Doing That?
© Kirby Lee-Imagn Images

At least for one week, USC looked the part of a super-power team again.

Yes, it was only against Missouri State - a brand new program to the FBS - but the offense was lights out in a 73-13 win.

The Big Ten season opener at Purdue is coming up next, but first, the attack needs to keep it rolling against a Georgia Southern team that’s far, far more dangerous than it showed in the opener.

Eagle head coach Clay Helton is used to USC, his former program, but coming off a rough 42-14 loss to Fresno State, the offense that has the pop has to be far more dangerous. But first …

USC vs Georgia Southern Prediction: Both Offenses Will Get Going

USC vs Georgia Southern How To Watch

Date: Saturday, September 6, 2025
Game Time: 7:30 PM ET
TV: FS1
Location: Los Angeles Memorial Coliseum, Los Angeles, CA
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Week 2 Big Game Expert Picks

Why Georgia Southern’s Defense Had Better Make the Trip

Fresno State lit up the Eagles like a Christmas tree. The Bulldog ground game gashed the Georgia Southern defensive front, rushing for 351 yards and averaging eight yards per carry.

No, the Eagle defense won’t get the job done, so the explosion on offense has to show up.

Quarterback JC French is a strong all-around playmaker, but he was contained last week after the first few drives. There were plenty of opportunities to take over, but it didn’t happen. In this, French and the passing game have to get going early.

Missouri State’s Jacob Clark was able to dink-and-dunk a little bit, but in this, the Eagle offense has to control the tempo right away. However …

USC’s Offense Will Be Flawless Again

Jayden Maiava threw for almost 300 yards with two scores, the running game rumbled at will, and overall, if the attack is as focused and sharp as it was last week, getting to 500 yards won’t be a breeze.

Georgia Southern forced Fresno State takeaways, and it didn’t matter. The Bulldogs ran at will, and USC’s ground game will do the same. Run well, set up the quarterbacks for easy throws, repeat. The Trojans will own third downs.

USC Won’t Roll Like Last Week, But It Won’t Be Far Off

Again, Georgia Southern is way better than it showed last week. Helton’s offenses can move, they have explosion, and none of that was apparent up the road in Fresno. There will be a little more pop early in this.

USC will come out a little rocky, and Georgia Southern might even have an early lead, and then everything will settle in, and bad things will happen from there.

USC vs Georgia Southern Prediction, Betting Lines

USC 48, Georgia Southern 17
Line: USC -28.5, o/u: 62
ATS Confidence out of 5: 3
Must See Rating: 2

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Consensus Line from BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

This article first appeared on College Football News and was syndicated with permission.

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