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The Louisville Cardinals and the Virginia Tech Hokies battled in a tough conference matchup which the Hokies won, 42-35. Hokies quarterback Hendon Hooker rushed for 68 yards and 3 touchdowns, and was a perfect 10 for 10 passing for 183 yards in the victory. Virginia Tech running back Khalil Herbert rushed for 147 yards and 1 touchdown. For Louisville, quarterback Malik Cunningham threw for 350 yards and 3 touchdowns, and running back Javian Hawkins ran for 129 yards and a touchdown.

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