The 20 greatest movies and TV shows starring real-life siblings

Jake and Maggie play on-screen siblings in this cult classic sci-fi thriller about a troubled teen visited by a giant rabbit named Frank. Their natural, slightly prickly chemistry adds a fantastic layer of realism to the film's surreal plot.

John and Joan have appeared in a whopping 10 movies together, but their banter here is top-tier. As a hitman and his long-suffering assistant, their back-and-forth over the phone is comedy gold. 

The Bridges brothers star as a pair of struggling lounge pianists who hire a singer to revitalize their act. Their incredible performances as siblings whose professional and personal lives begin to fray feel painfully real.

While the show famously starred father-son duo Eugene and Dan Levy, Dan's real-life sister, Sarah, also played a key role. She portrayed the endlessly sweet and slightly spacey Café Tropical waitress, Twyla Sands.

This movie is an absolute masterclass in sibling comedy, with Shawn and Marlon going to absurd lengths as FBI agents who go undercover as the vapid socialites they're assigned to protect. Their energy together is chaotic and over-the-top entertaining.

Before they were Oscar winners, Ben and Casey were just a couple of guys from Boston hanging out in the background of Good Will Hunting. Their townie-heckling scenes are minor, but they add to the movie's authentic, lived-in feel.

Luke and Owen Wilson star in this quirky Wes Anderson classic about a dysfunctional family of former child prodigies. Though they don't play brothers in the film, their distinct comedic styles are a perfect fit for the movie's theme.

Everyone knows Macaulay Culkin as Kevin McCallister, but his real-life younger brother, Kieran, played his bed-wetting, Pepsi-loving cousin, Fuller. It’s a small role, but iconic, nonetheless.

James directs and stars as the eccentric Tommy Wiseau, with his younger brother, Dave, playing Greg Sestero in this hilarious and surprisingly heartfelt movie about the making of a cult classic.

For an entire generation, these two were the definitive TV twin duo. Their Disney Channel show about two brothers living in a luxury hotel was a massive hit, built entirely around their perfect comedic timing.

It Takes Two is arguably the peak of the Olsen twins' cinematic empire. It's a charming '90s take on The Prince and the Pauper, where they play an orphan and a rich girl who swap lives, creating pure chaos. 

This 1980 Western pulled off a brilliant casting gimmick by having real-life acting brothers portray historical brothers. The film stars three sets of siblings: the Carradines (David, Keith, and Robert), the Quaids (Dennis and Randy), and the Keaches (Stacy and James).

Separated at birth, two identical twins with completely different personalities are accidentally reunited at a mall. The '90s sitcom that followed became a cultural touchstone, showcasing the incredible chemistry between Tia and Tamera.

Emilio Estevez and Charlie Sheen (who are the sons of Martin Sheen) share the screen as Billy the Kid and Dick Brewer in this classic '80s "Brat Pack" Western.

Two wealthy heiresses have their world turned upside down when a scandal leaves them penniless. It's a fun, fluffy 2000s comedy that was the perfect vehicle for the two sisters at the height of their fame. It's still a cheesy, early 2000s film that's just as entertaining today as it was nearly 20 years ago. 

Director Ron Howard has cast his younger brother Clint in nearly all of his movies. In this Oscar-winning drama, Clint has a memorable role as Sy Liebergot, the NASA flight controller who must deliver bad news to his superiors. Spooky and dramatic!

In a fun crossover moment, New Girl star Zooey guest guest-starred on her sister Emily's long-running TV show, Bones. She played Brennan's cousin, and their on-screen interactions were a treat for fans of both shows.

This beloved Disney Channel movie cast Tia and Tamera Mowry as "twitches," long-lost twin witches who discover their powers and a magical destiny on their 21st birthday. If you want to feel a hint of nostalgia, then be sure to turn this on during the Halloween season. 

The Wonder Years star Fred Savage made a memorable guest appearance on his younger brother Ben's hit show, Boy Meets World. He played a slick college professor who makes a pass at Topanga, leading to a classic confrontation with Cory.

The role that started it all saw both Olsen twins sharing the single part of Michelle Tanner, the adorable youngest daughter in this iconic family sitcom.