Purdue vs Southern Illinois Prediction: Barry Odom Era Off To a Hot Start

Purdue vs Southern Illinois How To Watch

Date: Saturday, September 6, 2025
Game Time: 7:30 PM ET
TV: BTN
Location: Ross-Ade Stadium, West Lafayette, IN
@PeteFiutak
Week 2 Big Game Expert Picks

Why Southern Illinois Will Win

Purdue is still trying to get all of the pieces together.

It might have dialed up the defense against Ball State, but the running game never found much of a groove. There were a few okay runs, but the line didn’t generate enough of a push - the Boilermakers averaged just 3.1 yards per carry.

The Salukis should be able to run well at times. They’ll grind more than flash, but …

Why Purdue Will Win

Purdue dialed up the pressure right out of the gate.

Barry Odom is the head coach - his teams will always bring a killer defense. Again, it was just Ball State, but the Boilermaker defensive front got its DoorDash order delivered in the Cardinal backfield.

Purdue will make SIU throw. It won’t always work, but the defensive attacking style should make up for a few mistakes here and there.

Purdue Won’t Shutout Southern Illinois, But …

The Boilermaker defense will look to make another statement.

After a disastrous 2024, there’s a real shot Purdue could at least be tied for the best scoring defense in the nation. It’ll be another crisp win before USC comes to town.

Purdue vs Southern Illinois Prediction, Betting Lines

Purdue 41, Southern Illinois 6
Line: COMING, o/u: COMING
ATS Confidence out of 5: COMING
Must See Rating: 1.5

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