Pirates Outfielder Back in Lineup vs. Cardinals

Bryan Reynolds returns to right field, taking over from Simon, and bats third again, while Jack Suwinski moves from center field to left field, coming in for Tommy Pham and batting sixth, completing the Pirates outfield.

Liover Peguero makes his second straight start, but moves from shortstop to second base, moving up one spot to eighth in the lineup.

Nick Gonzales won't start this game for the Pirates, marking the first game he's been in the dugout since Aug. 8 vs. the Cincinnati Reds at PNC Park.

Jared Triolo will move back to shortstop from third base, but take over as leadoff hitter from Simon, and Isiah Kiner-Falefa comes back in at third base and hits ninth. Spencer Horwitz stays at first base, but moves up two spots to second in the lineup, rounding out the Pirates infield.

Henry Davis returns at catcher and bats eighth, while Andrew McCutchen comes back in at designated hitter and bats fifth.

Right-handed starting pitcher Mitch Keller will make his 27th start of the season for the Pirates.

Keller struggled in his latest outing, allowing seven hits, three walks, a home run and five earned runs over 3.1 innings and 85 pitches thrown in a 7-3 defeat to the Blue Jays on Aug. 19.

He has pitched poorly in August, with a 1-2 record, a 9.00 ERA over 18.0 innings pitched, nine walks to 16 strikeouts, a .359 opposing batting average and a 2.06 WHIP.

Keller has had success vs. the Cardinals this season, with two scoreless outings at home on April 9 and July 2.

He pitched once at Busch Stadium earlier in 2025, giving up three earned runs over six innings pitched for a quality start, but took the loss in the 5-0 defeat, the final game of Derek Shelton's managerial tenure with the Pirates.

Keller has a 5-12 record over 26 starts in 2025, with a 4.34 ERA over 145.0 innings pitched, 116 strikeotus to 42 walks, a .259 opposing batting average and a 1.31 WHIP.

First pitch is set for 7:45 p.m. (EST).

Pittsburgh Pirates Lineup vs. the St. Louis Cardinals

SS Jared Triolo
1B Spencer Horwitz
RF Bryan Reynolds
CF Oneil Cruz
DH Andrew McCutchen
LF Jack Suwinski
C Henry Davis
2B Liover Peguero
3B Isiah Kiner-Falefa