Top 5 MLB Home Run Predictions Today: Exclusive Picks For May 7, 2026

While this is our long shot for today, it’s still hard to put Jarren Duran off the list. The Red Sox will open a series against the Tampa Bay Rays. Duran has the odds set to +600 and will hopefully crush his fifth MLB home run this season.

4. Alex Bregman +450

Bregman is having a slow start with the Chicago Cubs after crushing only three home runs. He’s slugging .245, and the Cubs have certainly expected more. However, there is plenty of time for this MLB season to unfold.

3. Gunnar Henderson +395

The Baltimore Orioles are picking up the pace, and Gunnar Henderson has been a bright spot. With nine home runs this MLB season, Henderson is trying to get his team on track. Watch out for the slugger to go deep as the O’s open a series against the Athletics.

2. Manny Machado +395

The San Diego Padres are still a threat to the Los Angeles Dodgers. Manny Machado is doing everything he can to carry the team forward. Machado has five homers, and the odds are set for +395 tonight. The Padres will open a series against the Cardinals.

1. Bryce Harper +376

The Philadelphia Phillies have struggled this MLB season, but Bryce Harper has not. The All-Star has nine home runs with a .277 batting average. Harper tops the list tonight to go deep as they finish their series against the Oakland Athletics.