49ers' Biggest Strengths—and the Weaknesses Broncos Can Exploit

McCaffrey is a threat in every phase, and the Broncos haven't fared well against running backs through three games. The Broncos will need a clear, concise plan if they want to prevent McCaffrey from taking over the game and making life extremely difficult for their defense. 

Much of the pressure will fall on the Broncos' linebackers and safeties, which is a concern given how Alex Singleton and Brandon Jones have played. Even so, defensive coordinator Vance Joseph has to key in on McCaffrey to give his defense the best chance for success. 

49ers' Offensive Weakness to Target: Colton McKivitz | RT

The 49ers don't really have an obvious weakness to attack on offense, but if I'm forced to call someone a weak link, it'd be McKivitz. He is actually having a good year so far, but he hasn't been overly challenged outside of the jet-lagged Rams defense.

This might be a game to use Nik Bonitto on the defensive left side of the line more frequently and match him up against McKivitz. 

Jonah Elliss has a poor matchup against McKivitz, but Que Robinson is the one to watch. Robinson has outplayed Elliss so far this season, so it will be interesting to see whether the Broncos change the rotation at outside linebacker, given how these two have played. 

49erd' Biggest Defensive Threat: Fred Warner | LB

Warner is one of the 49ers' few defensive weapons, and his game has few weaknesses. As with McCaffrey, Denver needs to find a way to handle Warner and keep him from taking over the game for the 49ers' defense. 

The problem is that the 49ers have a good defense that can still thrive without Warner being a major factor. They're disciplined, and the defense isn't overly complicated, making it easier for players to do their jobs and play fast. 

Let's hope the Broncos have a plan for Warner.

49ers' Defensive Weakness to Target: Osa Odighizuwa | DL

Odighizuwa is a fine player, but he is the 49ers' clear weak link on defense. He offers minimal pass-rush impact and looks like a liability against the run.

The 49ers' linebackers have largely covered Odighizuwa's issues, but Denver should be able to attack him in the run game for moderate success. 

Left guard Ben Powers and right guard Quinn Meinerz should be able to handle Odighizuwa in both phases of the game. The 49ers don't have the best depth on their defensive line, so neutralizing Odighizuwa will go a long way toward limiting the unit's overall impact.