For as talented as San Francisco 49ers running back Christian McCaffrey is, the most significant knock against the two-time All-Pro is how little we see him play.
McCaffrey only played double-digit games twice from 2020-24, though he easily ranked among the league’s top players when healthy. However, it’s hard not to cringe or worry when McCaffrey takes a hard hit or comes up slow midway through a 49ers’ drive.
After initially listing McCaffrey as questionable ahead of a Week 1 showdown with the Seattle Seahawks, the 49ers watched the three-time Pro Bowler pick up 142 yards on 31 touches. Various injuries to teammates, including reliable tight end George Kittle, forced McCaffrey to carry (pun not intended) the load in a 17-13 road victory.
There goes CMC!
— NFL (@NFL) September 7, 2025
SFvsSEA on FOXhttps://t.co/HkKw7uXVnt pic.twitter.com/8J3egaTCPQ
Unfortunately for McCaffrey, he likely won’t have much time to rest against the New Orleans Saints in Week 2. Not only did the 49ers place Kittle on injured reserve with a hamstring problem, but head coach Kyle Shanahan acknowledged that quarterback Brock Purdy could miss multiple weeks with a turf toe variant. Veteran receiver Jauan Jennings, who had two catches for 16 yards last Sunday, also sat out Wednesday’s practice with a shoulder issue.
Based on how the 49ers handled McCaffrey’s snaps and touches against the Seahawks, it’s hard not to start feeling concerned about his risk of injury moving forward.
We’re well aware that players can get hurt at any time in any situation. The Los Angeles Chargers lost All-Pro left tackle Rashawn Slater to a season-ending patellar tendon injury during an August practice.
Still, can you blame anyone for worrying about McCaffrey? He played 76% of the 49ers’ offensive snaps last Sunday, trailing only receiver Ricky Pearsall (84%) among offensive skill players. Meanwhile, recently-acquired running back Brian Robinson only played 18 snaps (24%) and had 10 touches for 37 yards.
As unfair as it might seem to McCaffrey, the 49ers need to ensure that they work Robinson more into the running back rotation. San Francisco cannot afford another McCaffrey injury, especially not when their offense is already missing several key players.
For his part, McCaffrey dismissed the idea on Wednesday that his recent calf problem was anything significant.
“I knew I was gonna play,” McCaffrey told reporters. “I just wanted to be smart with it.”
Fair enough. It’s time, though, for the 49ers to be “smart with it” and limit McCaffrey’s snaps when appropriate, even if it’s as simple as sitting him early in a blowout. The last thing that the 49ers need, especially considering their Super Bowl hopes, is to watch McCaffrey land on IR again.
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