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49ers vs. Seahawks in Week 5: Preview, notes, odds
Darren Yamashita-Imagn Images

The San Francisco 49ers hit the road as they travel to Lumen Field to take on the Seattle Seahawks. This matchup marks the 58th all-time meeting between the two teams and the first of two regular-season meetings. The 49ers have won four consecutive regular-season matchups at Lumen Field and look to improve to 5-0 on the year for the second time in four seasons (2023).

Previous game

The 49ers are coming off a 24-14 victory over the Denver Broncos. On offense, QB Brock Purdy completed 19 of 30 passes for 218 yards and two touchdowns. TE George Kittle caught four passes for 70 yards and one touchdown, while WR Deebo Samuel Sr. caught five for 26 yards and one touchdown, along with three carries for 44 yards. WR Mike Evans added five catches for 76 yards to lead the team, and RB Christian McCaffrey tallied 15 carries for 52 yards and one touchdown on the ground, along with three receptions for 18 yards through the air.

Defensively, San Francisco held Denver to 82 rushing yards. LB Dre Greenlaw led the unit with a team-high 12 tackles and one forced fumble. LB Fred Warner added seven tackles and two passes defensed, while DB Siran Neal recorded one tackle, one forced fumble, and one fumble recovery on special teams.

The 49ers Communications staff provided the above breakdown.

Below is everything you need to know to follow the upcoming game.

When does the game start?

Sunday, October 11 at 1:25 p.m. PT

Where is the game being played?

Lumen Field in Seattle, Washington

Who are the head coaches?

49ers: Kyle Shanahan
Seahawks: Mike Macdonald

Betting Odds

As of October 7, the Seahawks are favored by three points in this game, with an over/under set at 46 points, per BetMGM.

What channel is the game on?

Network: FOX
Play-By-Play: Kevin Burkhardt
Color Analyst: Tom Brady
Sideline Reporter: Erin Andrews
Sideline Reporter: Tom Rinaldi

Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.

What areas will receive the broadcast?

The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.

Via 49ers Webzone

Where can I stream the game?

NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the game in its entirety once the matchup is completed.

Bay Area fans can stream the game through the official 49ers app or at 49ers.com.

Where can I listen to the radio broadcast?

49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.

Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.

Seahawks Radio
Seattle area fans can listen on Seattle Sports 710 AM and KIRO 97.3 FM, where Steve Raible and Dave Wyman will call the game.

National Radio
Fans can listen to the game on Sports USA Radio, where Larry Kahn and Bryan Walters will call the game.

Streaming
NFL+ subscribers can listen to the game through that service.

Game discussion

Fans can discuss the game within our Niner Talk forum.

How has this series played out historically?

Matchups: 57
Series Record: Seahawks lead series 33-24
49ers Home Record vs. Seahawks: Seahawks lead series 15-12
49ers Away Record vs. Seahawks: Seahawks lead series 18-12
First Meeting: 9/26/76, 49ers win 37-21, at Sea.
Last Meeting: 1/17/26, Seahawks win 41-6, at Sea. (d)
Current Streak: Lost 2
Longest 49ers Win Streak: 6 (9/18/22 – 10/10/24)
Longest Seahawks Win Streak: 10 (1/19/14 – 12/2/18)
Most 49ers Points: 41 (1/14/23): 49ers win 41-23, at SF (w)
Most Seahawks Points: 43 (12/2/18): Seahawks win 43-16, at Sea.
49ers Shutouts: None
Seahawks Shutouts: 2 (Last 11/12/07), Seahawks win 24-0, at Sea.
(w) - Wild Card Game; (d) - Divisional Game

49ers Notes

  • 49ers are 4-0 for the 4th time since 1990 (1990, 2019 & 2023).
  • QB Brock Purdy completed 19 of 30 pass attempts (63.3 pct.) for 218 yards & 2 TDs for a 107.4 rating in Week 4. Aims for 5th in a row with 2+ TD passes. Is only QB with 2+ TD passes & 100+ rating in each of the 1st 4 weeks. Had TD pass in 6 of his past 7 vs. Sea.
  • RB Christian McCaffrey had 70 scrimmage yards (52 rush, 18 rec.) & rush TD in Week 4. Is 4th player ever (Warrick Dunn & HOFers Eric Dickerson & Marshall Faulk) with 6,000+ scrimmage yards with 2 teams (7,272 w/ Car.) (6,047 w/ SF). Has 100+ scrimmage yards in 7 of his past 8 vs. Sea. Ranks 2nd with 13,319 scrimmage yards (7,807 rush, 5,512 rec.) & 3rd with 102 scrimmage TDs (66 rush, 36 rec.) since 2017.
  • WR Mike Evans led team with 5 receptions for 76 yards in Week 4. Has 110 career TD catches & needs 1 TD catch to tie HOF Tony Gonzalez (111) for 9th most in NFL history.
  • WR Deebo Samuel had TD reception in Week 4 & has TD catch in 3 of his past 4. Had 102 rec. yards & TD catch in last game at Sea. (10/10/24).
  • TE George Kittle had 4 catches for 70 yards & TD in Week 4. Aims for 4th in a row with TD reception. Has TD catch in 3 of his past 4 vs. Sea.
  • LB Dre Greenlaw led team with 12 tackles & had FF in Week 4. Aims for 4th in a row with 8+ tackles. Has 8+ tackles in 6 of his past 7 vs. Sea.
  • LB Fred Warner had 7 tackles & 2 PD in Week 4. Ranks tied-5th with 40 tackles this season. Has 8+ tackles in 3 of his past 4 vs. Sea.
  • CB Upton Stout had 6 tackles in Week 4. Has 5+ tackles in 2 of his past 3.
  • CB Renardo Green had 2 PD in last road meeting. Only CB in NFL this season with 13+ tackles in a single game.
  • S Malik Mustapha had PD in Week 4. Had INT in last game at Sea. (10/10/24). Has 7+ tackles in 2 of his past 3 on road.

Seahawks Notes

  • QB Sam Darnold had 2 TD passes & a 94.5 rating in Week 4. Aims for 3rd in a row with TD pass. In 2025, became 4th QB ever to win Super Bowl in 1st season with team, joining Tom Brady, Trent Dilfer & Matthew Stafford.
  • RB Emanuel Wilson had 120 scrimmage yards (81 rush, 39 rec.) & 2 TDs (1 rush, 1 rec.) in Week 4. Has 90+ scrimmage yards in 2 of his past 3.
  • WR Rashid Shaheed had rush TD in Week 4.
  • WR Jaxon Smith-Njigba led team with 5 receptions for 76 yards in Week 4. Leads NFL with 6 TD receptions & ranks 3rd with 481 rec. yards in 2026. Has 120+ rec. yards & TD catch in 3 of his past 4. Ranks 5th with 4,032 rec. yards since 2023. Aims for 4th in a row with 80+ rec. yards & 5th in a row with 5+ receptions vs. SF. Had rec. TD in 2025 NFC-D vs. SF.
  • LB Ernest Jones IV led team with 12 tackles & had sack, TFL, INT & PD in Week 4, his 4th consecutive game with 8+ tackles, tied for the longest active streak in NFL this season (Alex Singleton, Anthony Hill & Jihaad Campbell). Aims for 3rd in a row with PD. Aims for 8th in a row with 5+ tackles vs. SF. Had INT in Week 1 meeting last season. Had INT & FF in 2025 NFC-D vs. SF.
  • LB Drake Thomas had 5 tackles, TFL, INT & PD in Week 4. Aims for 5th in a row with 5+ tackles & TFL. Aims for 3rd in a row at home with TFL. Had 5 tackles, 2 PD & INT in last meeting.
  • LB DeMarcus Lawrence had 2 TFL in Week 4. Aims for 3rd in a row with TFL. Had 6 tackles & 2 TFL in Week 1 meeting last season. Had sack & 2 FFs in 2025 NFC-D vs. SF.
  • CB Devon Witherspoon had 9 tackles & TFL in Week 4. Aims for 4th in a row with 6+ tackles. Has TFL in 2 of his past 3. Has 5+ tackles in 3 of his past 4 vs. SF.
  • S Nick Emmanwori had 9 tackles, 2 TFL, sack & PD in Week 4. Had 7 tackles & TFL in last meeting & aims for 3rd in a row vs. SF with TFL.
  • S Julian Love totaled 5 tackles & PD in Week 4.

This article first appeared on 49ers Webzone and was syndicated with permission.

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