Arizona Cardinals: Breaking News, Rumors & Highlights

Gameplan: How Cardinals Can Upset 49ers

One of the most volatile rivalries in the NFC West starts the season in Santa Clara, with the Arizona Cardinals visiting the San Francisco 49ers. Both of these teams are off to 2-0 starts, but they've also been marred by critical injuries.

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Cardinals’ Paris Johnson Jr., Will Johnson inactive vs. 49ers

The Arizona Cardinals will be without two more starters for Week 3’s game against the San Francisco 49ers. After being limited throughout the week of practice with a knee injury, starting left tackle Paris Johnson Jr.

NFL News / Arizona Cardinals on SI / September 21

3 Cardinals Who Can Flip the Script vs 49ers

The Arizona Cardinals are set to take on the San Francisco 49ers on the road this weekend to open NFC West division play. Arizona managed to sweep San Francisco last season, but things have changed since then.

NFL News / Arizona Cardinals on SI / September 21

Cardinals Must Contain These 49ers in Week 3

This Sunday marks the first NFC West division battle for the Arizona Cardinals as they head to the Bay Area to play the San Francisco 49ers. This series is tied at five wins each since 2020, but the Cardinals swept the Niners last season, including a 23-point blowout to end the season.

NFL News / Yardbarker Quizzes

The 'Multiple 30-TD pass NFL seasons' quiz

How many of the 34 NFL quarterbacks to throw 30 touchdown passes in a season on multiple occasions can you name in five minutes?

The 'NFL 200-touchdown-pass Club' quiz

The 'Active 300-passing-yard NFL games leaders' quiz

The 'Highest NFL passer ratings of all-time' quiz

Arizona Cardinals News / Arizona Cardinals on SI / September 21

5 Arizona Cardinals Who Must Step Up vs 49ers

We're hours away from kickoff between the Arizona Cardinals and San Francisco 49ers - and tension between the two NFC West sides continues to build. Injuries have ravaged both sides of the matchup, though both 2-0 squads aren't looking to make excuses.

NFL News / Yardbarker

25 NFL players who could retire after the 2025 season

NFL stars can't play forever, and retirement is coming sooner than later for some of the league's top players. These 25 players could call it quits following the 2025 season.

NFL News / Burn City Sports / September 21

Cardinals’ offensive line to be tested by 49ers’ front seven in Week 3

GLENDALE – The Arizona Cardinals offensive line to start the season have been lackluster. One of the strong suits of last year’s team has struggled to build a rhythm in 2025.

Arizona Cardinals News / Burn City Sports / September 21

How will the Cardinals secondary survive massive losses due to injuries in Week 3?

GLENDALE – The Arizona Cardinals couldn’t have any worse injury luck in Week 2 vs. the Carolina Panthers. All three of the team’s top cornerbacks exited the game due to injuries: Max Melton, Will Johnson and Garrett Williams.

NFL News / Burn City Sports / September 21

Latest Cardinals-49ers injury report ahead of Week 3 matchup

GLENDALE – The Arizona Cardinals and San Francisco 49ers have been banged up to start the 2025 season. The two teams submitted their latest injury report ahead of their Week 3 matchup, having key players on both sides questionable to compete.

NFL News / Arizona Cardinals on SI / September 21

Madden 26 Predicts Cardinals at 49ers Week 3 Matchup

The Arizona Cardinals and San Francisco 49ers both hope to keep their undefeated streaks alive today in Santa Clara - though only one NFC West squad can emerge victorious in Week 3.

NFL News / Arizona Cardinals on SI / September 21

Arizona Cardinals Fantasy Football Guide: Week 3 at San Francisco 49ers

The Arizona Cardinals head to Santa Clara, California, in Week 3 for a tough divisional matchup against the San Francisco 49ers. Vegas has San Francisco as the favorite at -2.5.

Kyler Murray News / Arizona Cardinals on SI / September 20

Everything Kyler Murray Said Ahead of Cardinals vs 49ers

It's a big week for the Arizona Cardinals and quarterback Kyler Murray. Murray, who will look to guide Arizona to a 3-0 start to the season, are road warriors this week as the San Francisco 49ers play host.

NFL News / Yardbarker

25 NFL quarterbacks from the 2000s who you already forgot about

As years go by, it's easy to forget some of the players who suited up on the gridiron. While the quarterback is the one position in the NFL that is under

Arizona Cardinals News / Arizona Cardinals on SI / September 20

Cardinals' Final Moves vs 49ers Reveals Cause for Concern

The Arizona Cardinals made their two standard practice squad elevations ahead of Week 3's road test against the San Francisco 49ers, and there might be cause for concern.

Arizona Cardinals News / Arizona Sports / September 20

Cardinals elevate linemen Jake Curhan, Anthony Goodlow to roster ahead of game vs. 49ers

The Arizona Cardinals elevated offensive lineman Jake Curhan and defensive lineman Anthony Goodlow from the practice squad Saturday ahead of their Week 4 game against the San Francisco 49ers.

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The 'NFL 200-touchdown-pass Club' quiz

The '2024 NFL passing TD leaders' quiz

The 'Switch-hitter single-season HR leaders' quiz

The 'Active three-TD catch NFL games' quiz

NFL News / Arizona Cardinals on SI / September 20

Cardinals Will Make Unique History vs 49ers

The Arizona Cardinals are the away team in Week 3's tilt against the San Francisco 49ers, though the organization will be wearing their all-red looks on the road - which will be a first.

NFL News / Arizona Cardinals on SI / September 20

49ers vs Cardinals Week 3 Preview

The Arizona Cardinals and San Francisco 49ers will meet in Santa Clara on Sunday for Week 3 action, giving Jonathan Gannon's squad their first NFC West tilt of the 2025 season.

NFL News / Total Apex Sports / September 19

Injury Report: Arizona Cardinals vs San Francisco – CB Will Johnson Is Doubtful Against 49ers

As the Arizona Cardinals prepare to face the San Francisco 49ers in a crucial Week 3 matchup, both teams are navigating significant injury concerns that could impact the game’s outcome.

Arizona Cardinals News / NFL on ClutchPoints / September 19

Cardinals’ Will Johnson, Paris Johnson Jr. get mixed injury update before Week 3 vs. 49ers

The Arizona Cardinals are set to take on the San Francisco 49ers in Week 3 in the hopes of advancing to a 3-0 record. Ideally, the roster is healthy and ready for the upcoming contest.

NFL News / Yardbarker / September 19

Cardinals' Campbell gives 49ers' Jones bulletin-board material

Cardinals' Calais Campbell gives 49ers' Mac Jones bulletin-board material

As of Friday morning, the Arizona Cardinals were uncertain whether they'd be facing Brock Purdy or Mac Jones at quarterback for the San Francisco 49ers in Sunday's game.

Kyle Shanahan has surprising Brock Purdy update — 49ers are confident in QB situation regardless

Will Mac Jones' solid play impact when 49ers bring Brock Purdy back?

49ers' Brock Purdy gives major hint about status for Cardinals game

The greatest seasons by undrafted NFL rookies

The 'Rookie Pro Bowlers since 2014' quiz

Kyler Murray News / Field Level Media / September 18

Kyler Murray sorry for wearing Vick jersey in pic with dog

Kyler Murray apologized for an image in a since-removed Instagram post in which the Arizona Cardinals quarterback is posing with his pit bull in a throwback Michael Vick No.

Marvin Harrison Jr. News / Yardbarker / September 18