Buffalo Bills quarterback Josh Allen. Chuck Cook-Imagn Images

Bills vs. Saints expert picks: Is anyone predicting a New Orleans win over Buffalo?

Originally posted on Buffalo Bills on SI
By Mike Moraitis | Last updated Sep 26, 2025 10:06 AM ET

The Week 4 game between the Buffalo Bills and New Orleans Saints features two teams going in completely opposite directions.

The Bills once again have their sights set on winning a Super Bowl in 2025 and are looking the part of an elite team following a 3-0 start to the season.

Meanwhile, the Saints are awful, as we all expected, and the team is in desperate need of a rebuild as it rides the fast track to a lost season.

As a result of their respective situations, the expectation is the Bills will go into Highmark Stadium on Sunday and crush the Saints.

Mark Konezny-Imagn Images

But that also sets this contest up to be the ultimate trap game for the Bills, something the NFL is infamous for.

With the Bills such a heavy favorite, is there any expert out there who is brave enough to pick the Saints? Let's find out.

ESPN

Stephania Bell: Bills

Matt Bowen: Bills

Mike Clay: Bills

Jeremy Fowler: Bills

Dan Graziano: Bills

Kalyn Kahler: Bills

Pamela Maldonado: Bills

Eric Moody: Bills

Jason Reid: Bills

Lindsey Thiry: Bills

Seth Wickersham: Bills

CBS Sports

Pete Prisco: Bills

Cody Benjamin: Bills

Jared Dubin: Bills

Ryan Wilson: Bills

John Breech: Bills

Tyler Sullivan: Bills

Dave Richard: Bills

Jamey Eisenberg: Bills

NFL.com

Ali Bhanpuri: Bills (33-17)

Tom Blair: Bills (31-14)

Brooke Cersosimo: Bills (43-23)

Gennaro Filice: Bills (32-17)

Dan Parr: Bills (34-14)

Vinnie Iyer, The Sporting News

Iyer: "The Saints don't have much of a run defense or downfield passing game. That plays right into the hands of Josh Allen and James Cook as Buffalo rolls a non-conference foe at home." Pick — Bills 34, Saints 17

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.