Chiefs RB Clyde Edwards-Helaire to play vs. Bills; Darrel Williams questionable

Edwards-Helaire has missed the last three games with a shoulder injury, while Williams was limited to one carry in the Chiefs' wild-card round win over the Pittsburgh Steelers five days ago and is dealing with a toe injury. Rashad Fenton is questionable due to a back ailment.

With Edwards-Helaire inactive against Pittsburgh and Williams going down early, Kansas City's backfield was sixth-year pro Jerick McKinnon, who produced 18 touches (12 rushing attempts and six receptions) for 142 yards from scrimmage and one touchdown catch. In 10 contests in 2021, Edwards-Helaire had 119 carries for 517 yards and four touchdowns, while adding 19 receptions for 129 yards and two scores through the air.

Williams recorded career-bests in rushing attempts (144), rushing yards (558), rushing touchdowns (six), targets (57), receptions (47), receiving yards (452) and receiving touchdowns (two) during the 2021 campaign. Fenton posted a career-high 49 tackles this season despite missing three games, also registering seven passes defended during the campaign, which tied his previous best mark from 2020.